Secretory Carcinoma of Salivary Gland with High-Grade Histology Arising in Hard Palate: A Case Report

• Published in: Reports (MDPI) 2020-03, Vol.3 (2), p.6
• Main Authors: Takabatake, Kiyofumi, Nakano, Keisuke, Kawai, Hotaka, Yoshida, Saori, Omori, Haruka, Wathone Oo, May, Qiusheng, Shan, Uchida, Kenichiro, Mishima, Katsuaki, Nagatsuka, Hitoshi
• Format: Article
• Language: English
• Subjects: Cancer metastasis; Cancer research; cervical lymph node metastasis; etv6-ntrk3 fusion; high-grade transformation; Salivary gland tumors; secretory carcinoma
• ISSN: 2571-841X; 2571-841X
• DOI: 10.3390/reports3020006

Secretory carcinoma (SC) is a recently described salivary gland tumor reported in the fourth edition of World Health Organization classification of head and neck tumors. SC is characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression, and harbors a t(12;15)(p13;q25) translocation which leads to ETV6-NTRK3 fusion product. Histologically, SC displays a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogenous or bubbly secretion. SC is generally recognized as low-grade malignancy with low-grade histopathologic features, and metastasis is relatively uncommon. In this case, we described a SC of hard palate that underwent high grade transformation and metastasis to the cervical lymph node in a 54-year-old patient. In addition, this case showed different histological findings between primary lesion and metastasis lesion. Therefore, the diagnosis was confirmed by the presence of ETV6 translocation. Here, we report a case that occurred SC with high-grade transformation in the palate, and a review of the relevant literature is also presented.