Parapapillary choroidal microvasculature dropout in eyes with primary open-angle glaucoma

• Published in: Scientific reports 2023-11, Vol.13 (1), p.20601-20601, Article 20601
• Main Authors: Igarashi, Ryoko, Ochiai, Shun, Akagi, Tadamichi, Miyamoto, Daiki, Sakaue, Yuta, Iikawa, Ryu, Fukuchi, Takeo
• Format: Article
• Language: English
• Subjects: 692/308/409; 692/699/3161/3172; Angiography; Atrophy; Correlation coefficient; Glaucoma; Glaucoma, Open-Angle; Humanities and Social Sciences; Humans; Intraocular Pressure; Microvasculature; Microvessels - diagnostic imaging; multidisciplinary; Nerve Fibers; Retinal Ganglion Cells; Science; Science (multidisciplinary); Tomography, Optical Coherence - methods
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-48102-8

The purpose of this study was to evaluate how various parameters are related to microvasculature dropout (MvD) area measured using optical coherence tomography angiography (OCTA). We measured the area of MvD in 55 patients with primary open-angle glaucoma (POAG). Using OCTA, MvD area and peripapillary choroidal atrophy (PPA) area were assessed in a 4.5 mm × 4.5 mm region. The following were examined: circumpapillary nerve fiber layer (cpRNFL) thickness, optic disc area, optic disc cupping area, optic disc rim area, Humphrey Field Analyzer (HFA) 24/10–2 mean deviation (MD), and pattern standard deviation (PSD). The relationship between MvD area and each parameter was evaluated using Spearman’s rank correlation coefficient analysis. Mean MvD area and PPA area were 0.18 ± 0.17 mm 2 and 1.13 ± 0.72 mm 2 , respectively. MvD area was significantly correlated with optic disc rim area ( p  = 0.0017), cpRNFL ( p  = 0.0027), HFA 24/10–2 MD, and PSD ( p