The evolution and adaptation of A-to-I RNA editing

Adenosine-to-inosine (A-to-I) RNA editing is an important post-transcriptional modification that affects the information encoded from DNA to RNA to protein. RNA editing can generate a multitude of transcript isoforms and can potentially be used to optimize protein function in response to varying con...

Full description

Saved in:
Bibliographic Details
Published in:PLoS genetics 2017-11, Vol.13 (11), p.e1007064-e1007064
Main Authors: Yablonovitch, Arielle L, Deng, Patricia, Jacobson, Dionna, Li, Jin Billy
Format: Article
Language:English
Subjects:
Acclimatization - genetics
Adaptation, Physiological - genetics
Adenosine - genetics
Adenosine - metabolism
Animals
Base Sequence - genetics
Biology and life sciences
Comparative analysis
Drosophila
Evolution, Molecular
Genetic aspects
Genomics - methods
Humans
Inosine - genetics
Inosine - metabolism
Research and Analysis Methods
Review
RNA - genetics
RNA - metabolism
RNA Editing - genetics
RNA Editing - physiology
RNA processing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Adenosine-to-inosine (A-to-I) RNA editing is an important post-transcriptional modification that affects the information encoded from DNA to RNA to protein. RNA editing can generate a multitude of transcript isoforms and can potentially be used to optimize protein function in response to varying conditions. In light of this and the fact that millions of editing sites have been identified in many different species, it is interesting to examine the extent to which these sites have evolved to be functionally important. In this review, we discuss results pertaining to the evolution of RNA editing, specifically in humans, cephalopods, and Drosophila. We focus on how comparative genomics approaches have aided in the identification of sites that are likely to be advantageous. The use of RNA editing as a mechanism to adapt to varying environmental conditions will also be reviewed.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1007064