Antibacterial and Cytotoxic Silica-Polycaprolactone-Chlorogenic Acid Hybrids by Sol-Gel Route

Organic-inorganic hybrid materials were synthesized by a sol-gel route, using silicon alkoxide together with low molecular weight polycaprolactone and caffetannic acid. The synthesized hybrids were characterized by scanning Fourier-transform infrared (FTIR) spectroscopy, and their surface morphology...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-04, Vol.28 (8), p.3486
Main Authors: Catauro, Michelina, D'Angelo, Antonio, Viola, Veronica, Cimmino, Giovanna, Pacifico, Severina
Format: Article
Language:English
Subjects:
Acids
Analysis
Anti-Bacterial Agents - pharmacology
Antibacterial agents
bioactivity
Biocompatibility
Biocompatible Materials - chemistry
Biological activity
Brain tumors
Chemical bonds
Chlorogenic acid
Chlorogenic Acid - chemistry
Cytotoxicity
Durapatite - chemistry
E coli
Escherichia coli
Food
FTIR spectroscopy
Hybrids
Hydroxyapatite
Low molecular weights
Microscopy, Electron, Scanning
Molecular weight
Polycaprolactone
Polymers
Scanning electron microscopy
Silica
Silicon Dioxide - chemistry
Sol-gel processes
Solvents
sol–gel
Spectroscopy, Fourier Transform Infrared
Tumor cell lines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Organic-inorganic hybrid materials were synthesized by a sol-gel route, using silicon alkoxide together with low molecular weight polycaprolactone and caffetannic acid. The synthesized hybrids were characterized by scanning Fourier-transform infrared (FTIR) spectroscopy, and their surface morphology was acquired by scanning electron microscopy (SEM) analysis. The hybrids were investigated for their antiradical capacity using the DPPH and ABTS tests, while the Kirby-Bauer test was used to evaluate their effects on the growth of and . Furthermore, a biologically active hydroxyapatite layer has been observed to form on the surface of intelligently synthesized materials. The MTT direct test showed that the hybrid materials are biocompatible with NIH-3T3 fibroblast cells, while they were cytotoxic towards colon, prostate, and brain tumor cell lines. These results shed new light on the suitability of the synthesized hybrids in the medical field, thus affording knowledge on the features of the bioactive silica-polycaprolactone-chlorogenic acid hybrids.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28083486