Experimental study on monitoring microwave ablation efficacy by real-time shear wave elastography in ex vivo porcine brain

• Published in: International journal of hyperthermia 2024, Vol.41 (1), p.2297649-2297649
• Main Authors: Li, Rui, Zhang, Yukang, Cheng, Linggang, Zheng, Shuai, Li, Hongbing, Zhang, Hongxia, Du, Lijuan, He, Wen, Zhang, Wei
• Format: Article
• Language: English
• Subjects: MWA; pathology; porcine brain; SWE
• ISSN: 0265-6736; 1464-5157
• DOI: 10.1080/02656736.2023.2297649

Glioma constitutes the most common primary malignant tumor in the central nervous system. In recent years, microwave ablation (MWA) was expected to be applied in the minimally invasive treatment of brain tumors. This study aims to evaluate the feasibility and accuracy of microwave ablation in brain tissue by Shear Wave Elastography (SWE) to explore the application value of real-time SWE in monitoring the process of MWA of brain tissue. Thirty brain tissues were treated with different microwave power and ablation duration. The morphologic and microscopic changes of MWA tissues were observed, and the diameter of the ablation areas was measured. In this experiment, SWE is used to quantitatively evaluate brain tissue's degree of thermal injury immediately after ablation. This study It is found that the ablation range measured by SWE after ablation is in good consistency with the pathological range [ICCSWEL1-L1 = 0.975(95% CI:0.959 - 0.985), ICCSWEL2-L2 = 0.887(95% CI:0.779 - 0.938)]. At the same time, the SWE value after ablation is significantly higher than before (mean ± SD,9.88 ± 2.64 kPa 23.6 ± 13.75 kPa;