Increased risk of subsequent benign prostatic hyperplasia in non-Helicobacter pylori-infected peptic ulcer patients: a population-based cohort study

The vagus nerve plays an essential role in homeostasis and inflammation. Clinically, peptic ulcer patients without helicobacter pylori (HP) infection may provide a population for studying the effect of vagal hyperactivity. There were interests in the association of gastrointestinal disease and uroge...

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Bibliographic Details
Published in:Scientific reports 2020-12, Vol.10 (1), p.21719-21719, Article 21719
Main Authors: Fang, Chu-Wen, Chen, Chun-Hao, Shen, Kun-Hung, Yang, Wen-Chi, Muo, Chih-Hsin, Wu, Shih-Chi
Format: Article
Language:English
Subjects:
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692/700
Adolescent
Adult
Age Factors
Aged
Cohort analysis
Cohort Studies
Gastrointestinal diseases
Genital diseases
Homeostasis
Humanities and Social Sciences
Humans
Hyperactivity
Hyperplasia
Incidence
Male
Middle Aged
multidisciplinary
Peptic Ulcer - complications
Peptic Ulcer - physiopathology
Peptic Ulcer - surgery
Peptic ulcers
Pharmacists
Population studies
Population-based studies
Prostatic Hyperplasia - epidemiology
Prostatic Hyperplasia - etiology
Risk
Science
Science (multidisciplinary)
Surgery
Taiwan - epidemiology
Time Factors
Ulcers
Vagotomy
Vagotomy, Truncal
Vagus nerve
Vagus Nerve - physiopathology
Young Adult
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Summary:The vagus nerve plays an essential role in homeostasis and inflammation. Clinically, peptic ulcer patients without helicobacter pylori (HP) infection may provide a population for studying the effect of vagal hyperactivity. There were interests in the association of gastrointestinal disease and urogenital disorders. Herein, we try to investigate subsequent risk of benign prostatic hyperplasia (BPH) in non-HP infected peptic ulcer patients. We identified 17,672 peptic ulcer admission male patients newly diagnosed in 1998–2007 from Taiwan Health Insurance Database, and 17,672 male comparison without peptic ulcer, frequency matched by age, and index-year. We assessed subsequent incidence of BPH in each cohort by the end of 2013, and then compared the risk of developing BPH between individuals with and without peptic ulcer. In addition, peptic ulcer patients underwent surgery were also examined. There were 2954 peptic ulcer patients and 2291 comparisons noted with the occurrence of BPH (25.35 and 16.70 per 1000 person-years, respectively). Compared to comparisons, peptic ulcer patients had a 1.45- and 1.26-fold BPH risk in multivariable Cox model and Fine and Gray model (95% CI 1.37–1.54 and 1.19–1.34). In age-stratified analysis, the highest risk of BPH was in 45–59 years (interaction p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-78913-y