The COVID-19 Cytokine Storm; What We Know So Far

COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory distress syndrome (ARDS) in about 15 % of the case...

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Bibliographic Details
Published in:Frontiers in immunology 2020-06, Vol.11, p.1446-1446
Main Authors: Ragab, Dina, Salah Eldin, Haitham, Taeimah, Mohamed, Khattab, Rasha, Salem, Ramy
Format: Article
Language:English
Subjects:
ARDS
COVID-19
cytokine
IL-6
Immunology
storm
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Summary:COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory distress syndrome (ARDS) in about 15 % of the cases. Mortality in COVID-19 patients has been linked to the presence of the so-called "cytokine storm" induced by the virus. Excessive production of proinflammatory cytokines leads to ARDS aggravation and widespread tissue damage resulting in multi-organ failure and death. Targeting cytokines during the management of COVID-19 patients could improve survival rates and reduce mortality.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.01446