Effects of single and combined exposure to BDE-47 and PFOA on distribution, bioaccumulation, and toxicity in blue mussel (Mytilus galloprovincialis)

• Published in: Ecotoxicology and environmental safety 2021-12, Vol.228, p.113014, Article 113014
• Main Authors: Geng, Qianqian, Guo, Mengmeng, Wu, Haiyan, Peng, Jixing, Zheng, Guanchao, Liu, Xiaoyu, Zhai, Yuxiu, Tan, Zhijun
• Format: Article
• Language: English
• Subjects: Bioconcentration; Biomarker; Blue mussel; Combined toxicity; New persistent organic pollutants
• ISSN: 0147-6513; 1090-2414
• DOI: 10.1016/j.ecoenv.2021.113014

The contamination of 2,2’,4,4’-Tetrabrmodiphenyl ether (BDE-47) and perfluorooctanoic acid (PFOA) has drawn a worldwide attention over the risks in ecological and food safety. In this work, blue mussel (Mytilus galloprpvincialis) was employed to investigate the combined effects of BDE-47 (10 ng mL-1) and PFOA (100 ng mL-1) on tissue distribution, accumulation, elimination, and toxicity. Results suggested that BDE-47 and PFOA accumulated mostly in digestive gland, followed by gills and gonad, and M. galloprovincialis displayed higher accumulation capacity to BDE-47 than PFOA. Co-exposure treatment reduced the accumulation of BDE-47, and enhanced the accumulation of PFOA. Furthermore, biochemical and histopathological tests revealed that the aggravated toxicity in co-exposure groups was mainly attributed to the oxidative stress and damage of tissue structure. This work could be helpful to get a better understanding of the combined behaviors and cumulative risks of BDE-47 and PFOA in marine ecosystem. [Display omitted] •BDE-47 and PFOA accumulated mostly in digestive gland, followed by gill and gonad.•M. galloprovincialis displayed higher accumulation capacity to BDE-47 than PFOA.•Co-exposure decreased BDE-47 accumulation, and increased PFOA accumulation.•Co-exposure aggravated the toxicity and residue risk of BDE-47 and PFOA in mussel.