The Intimate Connection Between Lipids and Hedgehog Signaling

Hedgehog (HH) signaling is an intercellular communication pathway involved in directing the development and homeostasis of metazoans. HH signaling depends on lipids that covalently modify HH proteins and participate in signal transduction downstream. In many animals, the HH pathway requires the prim...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2022-06, Vol.10, p.876815-876815
Main Authors: Nguyen, Thi D, Truong, Melissa E, Reiter, Jeremy F
Format: Article
Language:English
Subjects:
Cell and Developmental Biology
cholesterolyation
cilia
development
intercellular signaling
sterols
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Summary:Hedgehog (HH) signaling is an intercellular communication pathway involved in directing the development and homeostasis of metazoans. HH signaling depends on lipids that covalently modify HH proteins and participate in signal transduction downstream. In many animals, the HH pathway requires the primary cilium, an organelle with a specialized protein and lipid composition. Here, we review the intimate connection between HH signaling and lipids. We highlight how lipids in the primary cilium can create a specialized microenvironment to facilitate signaling, and how HH and components of the HH signal transduction pathway use lipids to communicate between cells.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.876815