Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy

Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tole...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in medicine 2021-07, Vol.8
Main Authors: Večerić-Haler, Željka, Kojc, Nika, Sever, Matjaž, Zver, Samo, Švajger, Urban, Poženel, Primož, Hartman, Katrina, Urdih, Tereza, Mlinšek, Gregor, Oblak, Manca, Aleš Rigler, Andreja, Ihan, Alojz, Buturović Ponikvar, Jadranka, Halloran, Philip P., Arnol, Miha
Format: Article
Language:English
Subjects:
autologous stem cell
kidney graft
kidney graft failure
kidney transplant
Medicine
mesenchymal stem cell
stem cell transplant
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c406t-168e0b15499177737dbd31f4cec40fd722ce6bca8d56e0a1df6b8933baf4900d3
cites cdi_FETCH-LOGICAL-c406t-168e0b15499177737dbd31f4cec40fd722ce6bca8d56e0a1df6b8933baf4900d3
container_end_page
container_issue
container_start_page
container_title Frontiers in medicine
container_volume 8
creator Večerić-Haler, Željka
Kojc, Nika
Sever, Matjaž
Zver, Samo
Švajger, Urban
Poženel, Primož
Hartman, Katrina
Urdih, Tereza
Mlinšek, Gregor
Oblak, Manca
Aleš Rigler, Andreja
Ihan, Alojz
Buturović Ponikvar, Jadranka
Halloran, Philip P.
Arnol, Miha
description Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tolerated with no serious safety concerns. No results are available on the use of MSCs in the late post-transplant period. Here, we present a case report of a severe systemic complication mimicking capillary leak syndrome with ultimate kidney transplant failure after autologous transplantation of MSCs used as rescue treatment of late antibody-mediated kidney allograft rejection.
doi_str_mv 10.3389/fmed.2021.708744
format article
fullrecord <record><control><sourceid>pubmedcentral_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_a6adb45b32564318ba1507aca3e608c6</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_a6adb45b32564318ba1507aca3e608c6</doaj_id><sourcerecordid>pubmedcentral_primary_oai_pubmedcentral_nih_gov_8334176</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406t-168e0b15499177737dbd31f4cec40fd722ce6bca8d56e0a1df6b8933baf4900d3</originalsourceid><addsrcrecordid>eNpVkcFu1DAQhiMEolXpnaNfYBc7dmyHA1IVsVB1ERJdBDdrbE92U5w4srNFeXuyXYToaUbzaz5p5iuKt4yuOdf1u7ZHvy5pydaKaiXEi-KyLGu50pX--fK__qK4zvmBUsp4WQnGXxcXXHCpWa0vi8cGMpJvOMY0vScNjF0IkGayRfhF7ufBp9gj-dFNB3LX-QFnsksw5DHAMJENdOGYkGxiCPF3N-zJzXGKIe7jMZMvmHFwh7mHQO4n7EmDIZDdAROM85viVQsh4_XfelV833zcNZ9X26-fbpub7coJKqcVkxqpZZWoa6aU4spbz1krHC5561VZOpTWgfaVRArMt9LqmnMLragp9fyquD1zfYQHM6auX44zETrzNIhpbyBNnQtoQIK3orLLk6TgTFtgFVXggKOk2smF9eHMGo92eb3DYUoQnkGfJ0N3MPv4aDTngqkTgJ4BLsWcE7b_dhk1J6XmpNSclJqzUv4HmoqWcg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy</title><source>PubMed Central</source><creator>Večerić-Haler, Željka ; Kojc, Nika ; Sever, Matjaž ; Zver, Samo ; Švajger, Urban ; Poženel, Primož ; Hartman, Katrina ; Urdih, Tereza ; Mlinšek, Gregor ; Oblak, Manca ; Aleš Rigler, Andreja ; Ihan, Alojz ; Buturović Ponikvar, Jadranka ; Halloran, Philip P. ; Arnol, Miha</creator><creatorcontrib>Večerić-Haler, Željka ; Kojc, Nika ; Sever, Matjaž ; Zver, Samo ; Švajger, Urban ; Poženel, Primož ; Hartman, Katrina ; Urdih, Tereza ; Mlinšek, Gregor ; Oblak, Manca ; Aleš Rigler, Andreja ; Ihan, Alojz ; Buturović Ponikvar, Jadranka ; Halloran, Philip P. ; Arnol, Miha</creatorcontrib><description>Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tolerated with no serious safety concerns. No results are available on the use of MSCs in the late post-transplant period. Here, we present a case report of a severe systemic complication mimicking capillary leak syndrome with ultimate kidney transplant failure after autologous transplantation of MSCs used as rescue treatment of late antibody-mediated kidney allograft rejection.</description><identifier>ISSN: 2296-858X</identifier><identifier>EISSN: 2296-858X</identifier><identifier>DOI: 10.3389/fmed.2021.708744</identifier><identifier>PMID: 34368198</identifier><language>eng</language><publisher>Frontiers Media S.A</publisher><subject>autologous stem cell ; kidney graft ; kidney graft failure ; kidney transplant ; Medicine ; mesenchymal stem cell ; stem cell transplant</subject><ispartof>Frontiers in medicine, 2021-07, Vol.8</ispartof><rights>Copyright © 2021 Večerić-Haler, Kojc, Sever, Zver, Švajger, Poženel, Hartman, Urdih, Mlinšek, Oblak, Aleš Rigler, Ihan, Buturović Ponikvar, Halloran and Arnol. 2021 Večerić-Haler, Kojc, Sever, Zver, Švajger, Poženel, Hartman, Urdih, Mlinšek, Oblak, Aleš Rigler, Ihan, Buturović Ponikvar, Halloran and Arnol</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-168e0b15499177737dbd31f4cec40fd722ce6bca8d56e0a1df6b8933baf4900d3</citedby><cites>FETCH-LOGICAL-c406t-168e0b15499177737dbd31f4cec40fd722ce6bca8d56e0a1df6b8933baf4900d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334176/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334176/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids></links><search><creatorcontrib>Večerić-Haler, Željka</creatorcontrib><creatorcontrib>Kojc, Nika</creatorcontrib><creatorcontrib>Sever, Matjaž</creatorcontrib><creatorcontrib>Zver, Samo</creatorcontrib><creatorcontrib>Švajger, Urban</creatorcontrib><creatorcontrib>Poženel, Primož</creatorcontrib><creatorcontrib>Hartman, Katrina</creatorcontrib><creatorcontrib>Urdih, Tereza</creatorcontrib><creatorcontrib>Mlinšek, Gregor</creatorcontrib><creatorcontrib>Oblak, Manca</creatorcontrib><creatorcontrib>Aleš Rigler, Andreja</creatorcontrib><creatorcontrib>Ihan, Alojz</creatorcontrib><creatorcontrib>Buturović Ponikvar, Jadranka</creatorcontrib><creatorcontrib>Halloran, Philip P.</creatorcontrib><creatorcontrib>Arnol, Miha</creatorcontrib><title>Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy</title><title>Frontiers in medicine</title><description>Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tolerated with no serious safety concerns. No results are available on the use of MSCs in the late post-transplant period. Here, we present a case report of a severe systemic complication mimicking capillary leak syndrome with ultimate kidney transplant failure after autologous transplantation of MSCs used as rescue treatment of late antibody-mediated kidney allograft rejection.</description><subject>autologous stem cell</subject><subject>kidney graft</subject><subject>kidney graft failure</subject><subject>kidney transplant</subject><subject>Medicine</subject><subject>mesenchymal stem cell</subject><subject>stem cell transplant</subject><issn>2296-858X</issn><issn>2296-858X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkcFu1DAQhiMEolXpnaNfYBc7dmyHA1IVsVB1ERJdBDdrbE92U5w4srNFeXuyXYToaUbzaz5p5iuKt4yuOdf1u7ZHvy5pydaKaiXEi-KyLGu50pX--fK__qK4zvmBUsp4WQnGXxcXXHCpWa0vi8cGMpJvOMY0vScNjF0IkGayRfhF7ufBp9gj-dFNB3LX-QFnsksw5DHAMJENdOGYkGxiCPF3N-zJzXGKIe7jMZMvmHFwh7mHQO4n7EmDIZDdAROM85viVQsh4_XfelV833zcNZ9X26-fbpub7coJKqcVkxqpZZWoa6aU4spbz1krHC5561VZOpTWgfaVRArMt9LqmnMLragp9fyquD1zfYQHM6auX44zETrzNIhpbyBNnQtoQIK3orLLk6TgTFtgFVXggKOk2smF9eHMGo92eb3DYUoQnkGfJ0N3MPv4aDTngqkTgJ4BLsWcE7b_dhk1J6XmpNSclJqzUv4HmoqWcg</recordid><startdate>20210721</startdate><enddate>20210721</enddate><creator>Večerić-Haler, Željka</creator><creator>Kojc, Nika</creator><creator>Sever, Matjaž</creator><creator>Zver, Samo</creator><creator>Švajger, Urban</creator><creator>Poženel, Primož</creator><creator>Hartman, Katrina</creator><creator>Urdih, Tereza</creator><creator>Mlinšek, Gregor</creator><creator>Oblak, Manca</creator><creator>Aleš Rigler, Andreja</creator><creator>Ihan, Alojz</creator><creator>Buturović Ponikvar, Jadranka</creator><creator>Halloran, Philip P.</creator><creator>Arnol, Miha</creator><general>Frontiers Media S.A</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210721</creationdate><title>Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy</title><author>Večerić-Haler, Željka ; Kojc, Nika ; Sever, Matjaž ; Zver, Samo ; Švajger, Urban ; Poženel, Primož ; Hartman, Katrina ; Urdih, Tereza ; Mlinšek, Gregor ; Oblak, Manca ; Aleš Rigler, Andreja ; Ihan, Alojz ; Buturović Ponikvar, Jadranka ; Halloran, Philip P. ; Arnol, Miha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-168e0b15499177737dbd31f4cec40fd722ce6bca8d56e0a1df6b8933baf4900d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>autologous stem cell</topic><topic>kidney graft</topic><topic>kidney graft failure</topic><topic>kidney transplant</topic><topic>Medicine</topic><topic>mesenchymal stem cell</topic><topic>stem cell transplant</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Večerić-Haler, Željka</creatorcontrib><creatorcontrib>Kojc, Nika</creatorcontrib><creatorcontrib>Sever, Matjaž</creatorcontrib><creatorcontrib>Zver, Samo</creatorcontrib><creatorcontrib>Švajger, Urban</creatorcontrib><creatorcontrib>Poženel, Primož</creatorcontrib><creatorcontrib>Hartman, Katrina</creatorcontrib><creatorcontrib>Urdih, Tereza</creatorcontrib><creatorcontrib>Mlinšek, Gregor</creatorcontrib><creatorcontrib>Oblak, Manca</creatorcontrib><creatorcontrib>Aleš Rigler, Andreja</creatorcontrib><creatorcontrib>Ihan, Alojz</creatorcontrib><creatorcontrib>Buturović Ponikvar, Jadranka</creatorcontrib><creatorcontrib>Halloran, Philip P.</creatorcontrib><creatorcontrib>Arnol, Miha</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Večerić-Haler, Željka</au><au>Kojc, Nika</au><au>Sever, Matjaž</au><au>Zver, Samo</au><au>Švajger, Urban</au><au>Poženel, Primož</au><au>Hartman, Katrina</au><au>Urdih, Tereza</au><au>Mlinšek, Gregor</au><au>Oblak, Manca</au><au>Aleš Rigler, Andreja</au><au>Ihan, Alojz</au><au>Buturović Ponikvar, Jadranka</au><au>Halloran, Philip P.</au><au>Arnol, Miha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy</atitle><jtitle>Frontiers in medicine</jtitle><date>2021-07-21</date><risdate>2021</risdate><volume>8</volume><issn>2296-858X</issn><eissn>2296-858X</eissn><abstract>Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tolerated with no serious safety concerns. No results are available on the use of MSCs in the late post-transplant period. Here, we present a case report of a severe systemic complication mimicking capillary leak syndrome with ultimate kidney transplant failure after autologous transplantation of MSCs used as rescue treatment of late antibody-mediated kidney allograft rejection.</abstract><pub>Frontiers Media S.A</pub><pmid>34368198</pmid><doi>10.3389/fmed.2021.708744</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2296-858X
ispartof Frontiers in medicine, 2021-07, Vol.8
issn 2296-858X
2296-858X
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_a6adb45b32564318ba1507aca3e608c6
source PubMed Central
subjects autologous stem cell
kidney graft
kidney graft failure
kidney transplant
Medicine
mesenchymal stem cell
stem cell transplant
title Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T14%3A22%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmedcentral_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Case%20Report:%20Capillary%20Leak%20Syndrome%20With%20Kidney%20Transplant%20Failure%20Following%20Autologous%20Mesenchymal%20Stem%20Cell%20Therapy&rft.jtitle=Frontiers%20in%20medicine&rft.au=Ve%C4%8Deri%C4%87-Haler,%20%C5%BDeljka&rft.date=2021-07-21&rft.volume=8&rft.issn=2296-858X&rft.eissn=2296-858X&rft_id=info:doi/10.3389/fmed.2021.708744&rft_dat=%3Cpubmedcentral_doaj_%3Epubmedcentral_primary_oai_pubmedcentral_nih_gov_8334176%3C/pubmedcentral_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c406t-168e0b15499177737dbd31f4cec40fd722ce6bca8d56e0a1df6b8933baf4900d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/34368198&rfr_iscdi=true