Current approaches in laboratory testing for SARS-CoV-2

•All types and characteristics of available laboratory testing for SARS-CoV-2 were reviewed.•The selection strategies of testing and sampling sites were examined at different disease stages.•The choice of test depends on technical characteristics, clinical scenarios and requirements. The outbreak of...

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Bibliographic Details
Published in:International journal of infectious diseases 2020-11, Vol.100, p.7-9
Main Authors: Xu, Yuzhong, Cheng, Minggang, Chen, Xinchun, Zhu, Jialou
Format: Article
Language:English
Subjects:
Betacoronavirus
Clinical Laboratory Techniques - methods
Coronavirus Infections - diagnosis
COVID-19
COVID-19 Testing
Humans
Laboratory diagnosis
Laboratory testing
Novel coronavirus
Pandemics
Pneumonia, Viral - diagnosis
SARS-CoV-2
Sensitivity and Specificity
Short Communication
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Summary:•All types and characteristics of available laboratory testing for SARS-CoV-2 were reviewed.•The selection strategies of testing and sampling sites were examined at different disease stages.•The choice of test depends on technical characteristics, clinical scenarios and requirements. The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which began in Wuhan, Hubei Province, China, has rapidly spread to produce a global pandemic. It is now clear that person-to-person transmission of SARS-CoV-2 has been occurring and that the virus has been dramatically growing in recent months. Early, rapid and accurate diagnosis is of great significance for curtailing the spread of SARS-CoV-2. There are currently several diagnostic techniques (e.g. viral culture and nucleic acid amplification test) being used to detect the virus. However, the sensitivity and specificity of these methods are quite different, with the sample source and detection limit varying greatly. This study reviewed all types and characteristics of the currently available laboratory diagnostic assays for detecting SARS-CoV-2 infection and summarized the selection strategies of testing and sampling sites at different disease stages to improve the diagnostic accuracy of Coronavirus Disease 2019 (COVID-19).
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2020.08.041