A top-down view of the tumor microenvironment: structure, cells and signaling

It is well established that the tumor microenvironment (TME) contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular, and immune. Signaling molecules secreted by the tumor corrupts these cells to create "activated" stroma. Equally, the extracellular matri...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2015-05, Vol.3, p.33-33
Main Authors: Bhome, Rahul, Bullock, Marc D, Al Saihati, Hajir A, Goh, Rebecca W, Primrose, John N, Sayan, A Emre, Mirnezami, Alex H
Format: Article
Language:English
Subjects:
Cancer stroma
Cancer-associated fibroblast
Extracellular Matrix
MicroRNAs
Oncology
Tumor Microenvironment
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Summary:It is well established that the tumor microenvironment (TME) contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular, and immune. Signaling molecules secreted by the tumor corrupts these cells to create "activated" stroma. Equally, the extracellular matrix (ECM) contributes to tumor development and invasion by forming a biologically active scaffold. In this review we describe the key structural, cellular and signaling components of the TME with a perspective on stromal soluble factors and microRNAs (miRNAs).
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2015.00033