Challenging Aspects to Precise Health Strategies in Native Hawaiian and Other Pacific Islanders Using Statins

Cardiometabolic disorders (CD), including cardiovascular disease (CVD), diabetes, and obesity, are the leading cause of health concern in the United States (U.S.), disproportionately affecting indigenous populations such a Native Hawaiian and Other Pacific Islanders (NHOPI). Dyslipidemia, a prevalen...

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Bibliographic Details
Published in:Frontiers in public health 2022-02, Vol.10, p.799731-799731
Main Authors: Watanabe, Ligia M, Seale, Lucia A
Format: Article
Language:English
Subjects:
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - prevention & control
cultural values
dyslipidemia
Ethnicity
genetic variations
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Minority Groups
Native Hawaiian or Other Pacific Islander
Native Hawaiians and Other Pacific Islanders
obesity
Public Health
statin
United States
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Summary:Cardiometabolic disorders (CD), including cardiovascular disease (CVD), diabetes, and obesity, are the leading cause of health concern in the United States (U.S.), disproportionately affecting indigenous populations such a Native Hawaiian and Other Pacific Islanders (NHOPI). Dyslipidemia, a prevalent risk factor for the development and progression of CVD, is more prone to occur in NHOPI than other populations in the U.S. High-intensity statin therapy to reduce low-density lipoprotein cholesterol is associated with the prevention of CVD events. However, significant side-effects, such as muscle disorders, have been associated with its use. Different ethnic groups could experience variation in the prevalence of statin side effects due to sociodemographic, behavioral, and/or biological factors. Therefore, identifying the most impactful determinants that can be modified to prevent or reduce statin side effects for individuals from high-risk ethnic minority groups, such as NHOPI, can lead to more effective strategies to reduce health disparities. Thus, our Mini-Review explores the challenging aspects of public health precise strategies in NHOPI taking statins, including a culturally informed additional therapy that could positively impact the NHOPI population.
ISSN:2296-2565
2296-2565
DOI:10.3389/fpubh.2022.799731