The Role of IL-7 and IL-7R in Cancer Pathophysiology and Immunotherapy

Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well as in B cell maturation through the activation of the IL-7 receptor (IL-7R). IL-7 is closely associated with...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-09, Vol.23 (18), p.10412
Main Authors: Wang, Chunli, Kong, Lingzu, Kim, Seokmin, Lee, Sunyoung, Oh, Sechan, Jo, Seona, Jang, Inhwan, Kim, Tae-Don
Format: Article
Language:English
Subjects:
Amino acids
Apoptosis
Binding sites
Biology
Bone marrow
Cancer
Cancer immunotherapy
Cell activation
Cell cycle
Cell differentiation
Cell growth
Competition
Cytokines
Glucose
Homeostasis
IL-7
IL-7R signal
Immune system
Immunotherapy
Interleukin 7
Kinases
Leukemia
Lymphatic system
Lymphocytes
Lymphocytes T
Molecular weight
Proteins
Review
Roles
Signal transduction
Therapeutic applications
Thymus gland
Tumors
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Summary:Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well as in B cell maturation through the activation of the IL-7 receptor (IL-7R). IL-7 is closely associated with tumor development and has been used in cancer clinical research and therapy. In this review, we first summarize the roles of IL-7 and IL-7Rα and their downstream signaling pathways in immunity and cancer. Furthermore, we summarize and discuss the recent advances in the use of IL-7 and IL-7Rα as cancer immunotherapy tools and highlight their potential for therapeutic applications. This review will help in the development of cancer immunotherapy regimens based on IL-7 and IL-7Rα, and will also advance their exploitation as more effective and safe immunotherapy tools.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231810412