Intravenous antibiotics in preterm infants have a negative effect upon microbiome development throughout preterm life

Intestinal dysbiosis is implicated in the origins of necrotising enterocolitis and late-onset sepsis in preterm babies. However, the effect of modulators of bacterial growth (e.g. antibiotics) upon the developing microbiome is not well-characterised. In this prospectively-recruited, retrospectively-...

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Bibliographic Details
Published in:Gut pathogens 2023-04, Vol.15 (1), p.18-18, Article 18
Main Authors: Hutchinson, R A, Costeloe, K L, Wade, W G, Millar, M R, Ansbro, K, Stacey, F, Fleming, P F
Format: Article
Language:English
Subjects:
Analysis
Antibiotics
Birth weight
Dysbacteriosis
Enterocolitis
Gestational age
Infants
Infants (Premature)
Infection
Intestine
Microbiomes
Necrotizing enterocolitis
Neonates
Newborn babies
Population
Premature babies
RNA
rRNA 16S
Sepsis
Trends
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Summary:Intestinal dysbiosis is implicated in the origins of necrotising enterocolitis and late-onset sepsis in preterm babies. However, the effect of modulators of bacterial growth (e.g. antibiotics) upon the developing microbiome is not well-characterised. In this prospectively-recruited, retrospectively-classified, case-control study, high-throughput 16S rRNA gene sequencing was combined with contemporaneous clinical data collection, to assess the within-subject relationship between antibiotic administration and microbiome development, in comparison to preterm infants with minimal antibiotic exposure. During courses of antibiotics, diversity progression fell in comparison to that seen outside periods of antibiotic use (-0.71units/week vs. + 0.63units/week, p 
ISSN:1757-4749
1757-4749
DOI:10.1186/s13099-023-00544-1