Cognitive function in subclinical hypothyroidism in elderly

To study the association of cognitive function with subclinical hypothyroidism in elderly. It's a cross-sectional, case-control study of 103 patients (≥65 years) who met the criteria for subclinical hypothyroidism. Similarly 103 age, sex and education-matched healthy controls were taken. Serum...

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Bibliographic Details
Published in:Indian journal of endocrinology and metabolism 2014-11, Vol.18 (6), p.811-814
Main Authors: Bajaj, Sarita, Sachan, Shivam, Misra, Vatsala, Varma, Anurag, Saxena, Piyush
Format: Article
Language:English
Subjects:
Age
Aged patients
Cognition disorders
Cognitive ability
Cognitive impairment
Complications and side effects
Distribution
Education
elderly
Hypothyroidism
Original
Psychological aspects
Socioeconomic factors
Studies
subclinical hypothyroidism
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Summary:To study the association of cognitive function with subclinical hypothyroidism in elderly. It's a cross-sectional, case-control study of 103 patients (≥65 years) who met the criteria for subclinical hypothyroidism. Similarly 103 age, sex and education-matched healthy controls were taken. Serum TSH, free T3 and free T4 were measured. Cognitive functions were assessed by using Folstein Mini Mental Examination (MMSE) and clock drawing test. Out of the 103 diagnosed subclinical hypothyroidism cases, cognitive impairment (by MMSE) was found in 33 (30.9%) while it was present in only 15 (14.54%) out of 103 controls (P = 0.003), cognitive impairment (by CDT) was present in 32 patients (31.06%) out of 103 cases while it was present in 26 patients (25.24%) out of 103 controls (P > 0.05, insignificant). Mean TSH of subclinical hypothyroidism with cognitive impairment was 7.67 ± 1.22 mIU/liter and without cognitive impairment was 6.47 ± 0.98 mIU/liter (P value = 0.0001, significant). Prevalence of cognitive impairment was significantly higher in subclinical hypothyroidism as compared to controls. Presence of cognitive impairment correlated with the level of TSH; as TSH increased cognitive function declined.
ISSN:2230-8210
2230-9500
DOI:10.4103/2230-8210.141355