Surgical Applications of Materials Engineered with Antimicrobial Properties

The infection of surgically placed implants is a problem that is both large in magnitude and that broadly affects nearly all surgical specialties. Implant-associated infections deleteriously affect patient quality-of-life and can lead to greater morbidity, mortality, and cost to the health care syst...

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Bibliographic Details
Published in:Bioengineering (Basel) 2022-03, Vol.9 (4), p.138
Main Authors: Perrault, David P, Sharma, Ayushi, Kim, Jessica F, Gurtner, Geoffrey C, Wan, Derrick C
Format: Article
Language:English
Subjects:
antibacterial coating
Antibiotics
antifouling
Antifouling coatings
Antimicrobial peptides
Bioengineering
Biofilms
Catheters
Clinical trials
Dental implants
Drug resistance
Health care
Hydrophilic surfaces
implant coating
implant infection
Implants
Medical equipment
Metal ions
Morbidity
Mortality
nanostructured surface
Orthopedics
Patients
Peptides
Pharmacokinetics
Phenols
Polymers
Review
Stents
Surgical equipment
surgical site infection
Surgical site infections
Sutures
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Summary:The infection of surgically placed implants is a problem that is both large in magnitude and that broadly affects nearly all surgical specialties. Implant-associated infections deleteriously affect patient quality-of-life and can lead to greater morbidity, mortality, and cost to the health care system. The impact of this problem has prompted extensive pre-clinical and clinical investigation into decreasing implant infection rates. More recently, antimicrobial approaches that modify or treat the implant directly have been of great interest. These approaches include antibacterial implant coatings (antifouling materials, antibiotics, metal ions, and antimicrobial peptides), antibacterial nanostructured implant surfaces, and antibiotic-releasing implants. This review provides a compendium of these approaches and the clinical applications and outcomes. In general, implant-specific modalities for reducing infections have been effective; however, most applications remain in the preclinical or early clinical stages.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering9040138