Whole-Body Cryotherapy Increases the Activity of Nitric Oxide Synthase in Older Men

Aging causes oxidative stress, endothelial dysfunction and a reduction in the bioavailability of nitric oxide. The study aim was to determine whether, as a result of repeated whole-body exposure to cryogenic temperature (3 min −130 °C), there is an increase of inducible nitric oxide synthase (iNOS)...

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Published in:Biomolecules (Basel, Switzerland) Switzerland), 2021-07, Vol.11 (7), p.1041
Main Authors: Wiecek, Magdalena, Szygula, Zbigniew, Gradek, Joanna, Kusmierczyk, Justyna, Szymura, Jadwiga
Format: Article
Language:English
Subjects:
Aging
Atherosclerosis
Bioavailability
Body temperature
C-reactive protein
Cryotherapy
endurance athletes
Homocysteine
IL-1β
Immunoassay
Inflammation
Interleukin 10
Interleukin 6
Nitric oxide
Nitric-oxide synthase
Nitrotyrosine
Oxidative stress
Participation
Physical activity
Reagents
Skin
vasodilatation
Vegetarianism
whole-body cryostimulation
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Summary:Aging causes oxidative stress, endothelial dysfunction and a reduction in the bioavailability of nitric oxide. The study aim was to determine whether, as a result of repeated whole-body exposure to cryogenic temperature (3 min −130 °C), there is an increase of inducible nitric oxide synthase (iNOS) concentration in senior subjects (59 ± 6 years), and if this effect is stronger in athletes. In 10 long-distance runners (RUN) and 10 untraining (UTR) men, 24 whole-body cryotherapy (WBC) procedures were performed. Prior to WBC, after 12th and 24th treatments and 7 days later, the concentration of iNOS, asymmetric dimethylarginine (ADMA), 3-nitrotyrosine (3-NTR), homocysteine (HCY), C-reactive protein (CRP) and interleukins such as: IL-6, IL-1β, IL-10 were measured. In the RUN and UTR groups, after 24 WBC, iNOS concentration was found to be comparable and significantly higher (F = 5.95, p < 0.01) (large clinical effect size) compared to before 1st WBC and after 12th WBC sessions. There were no changes in the concentration of the remaining markers as a result of WBC (p > 0.05). As a result of applying 24 WBC treatments, using the every-other-day model, iNOS concentration increased in the group of older men, regardless of their physical activity level. Along with this increase, there were no changes in nitro-oxidative stress or inflammation marker levels.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom11071041