Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and LMNA and SCN5A Mutations

Bileaflet mitral valve prolapse (Bi-MVP) is associated with increased risk for cardiac arrest. We describe a patient who presented after a cardiac arrest with Bi-MVP and variants in Lamin A/C (LMNA) and the sodium channel alpha-subunit 5a (SCN5A). Genetic variants may be the culprit for arrhythmogen...

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Bibliographic Details
Published in:JACC. Case reports 2021-02, Vol.3 (2), p.242-246
Main Authors: Mahajan, Asha M., Itan, Yuval, Cerrone, Marina, Horowitz, James, Borneman, Linda, Chinitz, Larry, Jankelson, Lior
Format: Article
Language:English
Subjects:
genetic disorders
Mini-Focus Issue: Imaging
mitral valve
ventricular fibrillation
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Summary:Bileaflet mitral valve prolapse (Bi-MVP) is associated with increased risk for cardiac arrest. We describe a patient who presented after a cardiac arrest with Bi-MVP and variants in Lamin A/C (LMNA) and the sodium channel alpha-subunit 5a (SCN5A). Genetic variants may be the culprit for arrhythmogenesis in Bi-MVP patients. (Level of Difficulty: Intermediate.) [Display omitted]
ISSN:2666-0849
2666-0849
DOI:10.1016/j.jaccas.2020.11.046