Anatomy of corpus callosum in prenatally malnourished rats

The effect of prenatal malnutrition on the anatomy of the corpus callosum was assessed in adult rats (45-52 days old). In the prenatally malnourished animals we observed a significant reduction of the corpus callosum total area, partial areas, and perimeter, as compared with normal animals. In addit...

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Bibliographic Details
Published in:Biological research 2012, Vol.45 (1), p.87-92
Main Authors: Olivares, Ricardo, Morgan, Carlos, Pérez, Hernán, Hernández, Alejandro, Aboitiz, Francisco, Soto-Moyano, Rubén, Gil, Julio, Ortiz, Alexis, Flores, Osvaldo, Gimeno, Miguel, Laborda, Jesús
Format: Article
Language:English
Subjects:
Animals
BIOLOGY
Body Weight - physiology
Control Groups
corpus callosum
Corpus Callosum - anatomy & histology
Corpus Callosum - physiology
Female
Male
Malnutrition - pathology
Malnutrition - physiopathology
Nerve Fibers - ultrastructure
Nerve Fibers, Myelinated - ultrastructure
Pregnancy
Prenatal Exposure Delayed Effects - pathology
Prenatal Exposure Delayed Effects - physiopathology
prenatal malnutrition
rat
Rats
Rats, Sprague-Dawley
splenium
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Summary:The effect of prenatal malnutrition on the anatomy of the corpus callosum was assessed in adult rats (45-52 days old). In the prenatally malnourished animals we observed a significant reduction of the corpus callosum total area, partial areas, and perimeter, as compared with normal animals. In addition, the splenium of corpus callosum (posterior fifth) showed a significant decrease of fiber diameters in the myelinated fibers without changing density. There was also a significant decrease in diameter and a significant increase in density of unmyelinated fibers. Measurements of perimeter's fractal dimensions from sagittal sections of the brain and corpus callosum did not show significant differences between malnourished and control animals. These findings indicate that cortico-cortical connections are vulnerable to the prenatal malnutrition, and suggest this may affect interhemispheric conduction velocity, particularly in visual connections (splenium).
ISSN:0716-9760
0717-6287
DOI:10.4067/S0716-97602012000100012