Benefit-Risk Analysis of Buprenorphine for Pain Management

Health care providers in the United States are facing challenges in selecting appropriate medication for patients with acute and chronic pain in the midst of the current opioid crisis and COVID-19 pandemic. When compared with conventional opioids, the partial [micro]-opioid receptor agonist buprenor...

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Bibliographic Details
Published in:Journal of pain research 2021-01, Vol.14, p.1359-1369
Main Authors: Hale, Martin, Garofoli, Mark, Raffa, Robert B
Format: Article
Language:English
Subjects:
analgesia
Analgesics
Back pain
Buprenorphine
buprenorphine buccal film
Cancer
Care and treatment
Chronic pain
Comparative analysis
Complications and side effects
Constipation
COVID-19
Drug abuse
Drug approval
Drug dosages
Drug overdose
FDA approval
Fentanyl
Morphine
Narcotics
opioids
Ostomy
Pain
Pain management
Patient safety
Patient satisfaction
Review
Risk assessment
Surgery
Systematic review
Transdermal medication
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Summary:Health care providers in the United States are facing challenges in selecting appropriate medication for patients with acute and chronic pain in the midst of the current opioid crisis and COVID-19 pandemic. When compared with conventional opioids, the partial [micro]-opioid receptor agonist buprenorphine has unique pharmacologic properties that may be more desirable for pain management. The formulations of buprenorphine approved by the US Food and Drug Administration for pain management include intravenous injection, transdermal patch, and buccal film. A comparison of efficacy and safety data from studies of buprenorphine and conventional opioids suggests that buprenorphine may be a better-tolerated treatment option for many patients that provides similar or superior analgesia. Our benefit-risk assessment in this narrative review suggests that health care providers should consider that buprenorphine may be an appropriate alternative for pain management over other opioids. Keywords: buprenorphine, buprenorphine buccal film, analgesia, pain, opioids
ISSN:1178-7090
1178-7090
DOI:10.2147/JPR.S305146