Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe

• Published in: BMC cancer 2021-03, Vol.21 (1), p.281-281, Article 281
• Main Authors: Gaete, Stanie, Auguste, Aviane, Bhakkan, Bernard, Peruvien, Jessica, Herrmann-Storck, Cecile, Socrier, Youri, Diedhiou, Abdoulaye, Deloumeaux, Jacqueline
• Format: Article
• Language: English
• Subjects: Adult; Caribbean; Cervical cancer; Cervical Intraepithelial Neoplasia - epidemiology; Cervical Intraepithelial Neoplasia - pathology; Cervical Intraepithelial Neoplasia - prevention & control; Cervical Intraepithelial Neoplasia - virology; Cervix; Cervix Uteri - pathology; Cervix Uteri - virology; Coinfection - diagnosis; Coinfection - epidemiology; Coinfection - prevention & control; Coinfection - virology; Data collection; Deoxyribonucleic acid; Diagnosis; DNA; DNA, Viral - isolation & purification; Dysplasia; Ethics; Female; Genotype & phenotype; Genotypes; Genotyping; Guadeloupe; Guadeloupe - epidemiology; Histology; Human papilloma virus; Human papillomavirus; Human papillomavirus 16 - genetics; Human papillomavirus 16 - isolation & purification; Human papillomavirus 18 - genetics; Human papillomavirus 18 - isolation & purification; Humans; Hybridization; Immunization; Incidence; Invasiveness; ISO standards; Life Sciences; Medical screening; Middle Aged; Papillomavirus infections; Papillomavirus Infections - diagnosis; Papillomavirus Infections - epidemiology; Papillomavirus Infections - prevention & control; Papillomavirus Infections - virology; Papillomavirus Vaccines - administration & dosage; Paraffin; Pathology; Quality control; Retrospective Studies; Risk factors; Statistics; Tumors; Uterine Cervical Neoplasms - epidemiology; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - prevention & control; Uterine Cervical Neoplasms - virology; Womens health
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-021-07940-3

Cervical cancer is the fourth cancer worldwide. The Human Papilloma Virus is responsible for 99% of the cases but the distribution of its genotypes varies among populations. We aimed to identify HPV genotypes distribution in women with grade 2/3 cervical intraepithelial dysplasia or invasive cervical cancer in Guadeloupe, a French Caribbean territory with a population mainly of African descent. We used paraffin-embedded tumors for viral DNA extraction from women diagnosed between 2014 and 2016 and identified by the population-based cancer registry. The HPV Genotyping was performed with the InnoLIPA HPV Genotyping Extra kit®. Overall, 213 samples out of the 321 eligible records were analyzed. The HPV status was positive for 94% of the cases. The five most common oncogenic HPV genotypes were HPV31 (47%), HPV33 (38%), HPV16 (32%), HPV44 (31%) and HPV26 (28%). HPV18 was found in only in 5% of the cases. Among the studied cases, 94% had multiple infections. More than 60% of single infections were HPV16-related, accounting for 35% of HPV16 infections. These results show a different distribution of oncogenic HPVs in Guadeloupe with "31 >  33 > 16" and a high frequency of multiple infections. Despite a lower coverage, the nine-valent vaccine is nevertheless adequate.