Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway

This study explores the photoprotective effects of rutin, a bioflavonoid found in some vegetables and fruits, against UVA-induced damage in human skin fibroblasts. Our results show that rutin increases cell viability and reduces the high levels of ROS generated by photo-oxidative stress (1 and 2 h o...

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Bibliographic Details
Published in:Antioxidants 2023-03, Vol.12 (4), p.820
Main Authors: Tabolacci, Elisabetta, Tringali, Giuseppe, Nobile, Veronica, Duca, Sara, Pizzoferrato, Michela, Bottoni, Patrizia, Clementi, Maria Elisabetta
Format: Article
Language:English
Subjects:
Antibodies
Biopsy
Cell culture
Cell viability
Fibroblasts
Glutathione
Mitochondria
mitochondrial function
Nrf2 pathway
Oxidative stress
Proteins
Rutin
Signal transduction
Transcription activation
Ultraviolet radiation
UVA-induced damage
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Summary:This study explores the photoprotective effects of rutin, a bioflavonoid found in some vegetables and fruits, against UVA-induced damage in human skin fibroblasts. Our results show that rutin increases cell viability and reduces the high levels of ROS generated by photo-oxidative stress (1 and 2 h of UVA exposure). These effects are related to rutin's ability to modulate the Nrf2 transcriptional pathway. Interestingly, activation of the Nrf2 signaling pathway results in an increase in reduced glutathione and Bcl2/Bax ratio, and the subsequent protection of mitochondrial respiratory capacity. These results demonstrate how rutin may play a potentially cytoprotective role against UVA-induced skin damage through a purely antiapoptotic mechanism.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox12040820