Efferocytosis in dendritic cells: an overlooked immunoregulatory process

Efferocytosis, the process of engulfing and removing apoptotic cells, plays an essential role in preserving tissue health and averting undue inflammation. While macrophages are primarily known for this task, dendritic cells (DCs) also play a significant role. This review delves into the unique contr...

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Bibliographic Details
Published in:Frontiers in immunology 2024-05, Vol.15, p.1415573-1415573
Main Authors: Ma, Yanyan, Jiang, Tangxing, Zhu, Xun, Xu, Yizhou, Wan, Ke, Zhang, Tingxuan, Xie, Miaorong
Format: Article
Language:English
Subjects:
Animals
antigen cross-presentation
Apoptosis - immunology
apoptotic cell
dendritic cell
Dendritic Cells - immunology
Efferocytosis
Humans
immune regulation
Immune Tolerance
Immunology
Macrophages - immunology
Phagocytosis - immunology
Treg differentiation
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Summary:Efferocytosis, the process of engulfing and removing apoptotic cells, plays an essential role in preserving tissue health and averting undue inflammation. While macrophages are primarily known for this task, dendritic cells (DCs) also play a significant role. This review delves into the unique contributions of various DC subsets to efferocytosis, highlighting the distinctions in how DCs and macrophages recognize and handle apoptotic cells. It further explores how efferocytosis influences DC maturation, thereby affecting immune tolerance. This underscores the pivotal role of DCs in orchestrating immune responses and sustaining immune equilibrium, providing new insights into their function in immune regulation.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1415573