Bifocal pineal and suprasellar germinomas with posterior fossa metastases in an adolescent patient

Central nervous system germ cell tumors are rare lesions that are more frequently seen in the pediatric age group. Intracranial germinomas are a type of these germ cell tumors and commonly arise in the pineal region, suprasellar region, or less frequently at both areas (bifocal). Common features of...

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Bibliographic Details
Published in:Radiology case reports 2022-12, Vol.17 (12), p.4537-4541
Main Authors: Kumar, Virang, Mahdi, Eman, Moore, Nicholas, Vorona, Gregory, Mishra, Chakradhar, Jones, Kathryn, Urbine, Jacqueline
Format: Article
Language:English
Subjects:
Bifocal germinoma
Case Report
Germ cell tumor
MRI
Pinealoma
Suprasellar germinoma
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Summary:Central nervous system germ cell tumors are rare lesions that are more frequently seen in the pediatric age group. Intracranial germinomas are a type of these germ cell tumors and commonly arise in the pineal region, suprasellar region, or less frequently at both areas (bifocal). Common features of this tumor depend on the location of the lesion(s) and include Parinaud's syndrome, obstructive hydrocephalus, diabetes insipidus, panhypopituitarism, strabismus, and visual acuity defects. We report a case of bifocal pineal and suprasellar germinoma with posterior fossa metastases in a 15-year-old male patient. The involvement of the third ventricular floor and nonthickened inferior pituitary stalk of the suprasellar lesion suggest that it is a metastasis of a primary pineal lesion rather than a dual-primary. This distinction, with the presence of posterior fossa metastases, favors the use of more aggressive treatment with combination radiation therapy and chemotherapy for a better outcome.
ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2022.08.102