Pharmacokinetics and analgesic effects of intravenous, intramuscular or subcutaneous buprenorphine in dogs undergoing ovariohysterectomy: a randomized, prospective, masked, clinical trial

Buprenorphine is used for canine postoperative pain management. This study aimed to describe the pharmacokinetics and evaluate the analgesic efficacy of buprenorphine (Simbadol, 1.8 mg/mL) administered by different routes in dogs undergoing ovariohysterectomy. Twenty-four dogs were included in a ran...

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Bibliographic Details
Published in:BMC veterinary research 2020-05, Vol.16 (1), p.154-10, Article 154
Main Authors: Steagall, Paulo Vinicius, Ruel, Hélène Louise Marcelle, Yasuda, Tomoyo, Monteiro, Beatriz Paglerani, Watanabe, Ryota, Evangelista, Marina Cayetano, Beaudry, Francis
Format: Article
Language:English
Subjects:
Administration, Intravenous - veterinary
Analgesia
Analgesia - veterinary
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - pharmacokinetics
Anesthesia
Animals
Blood tests
Buprenorphine
Buprenorphine - administration & dosage
Buprenorphine - pharmacokinetics
Canine
Carprofen
Clinical trials
Dogs
Dogs - surgery
Female
Hysterectomy - veterinary
Injections, Intramuscular - veterinary
Injections, Subcutaneous - veterinary
Liquid chromatography
Mass spectrometry
Ovariectomy - veterinary
Ovariohysterectomy
Pain
Pain management
Pain Measurement - veterinary
Pain, Postoperative - drug therapy
Pain, Postoperative - veterinary
Product development
Prospective Studies
Simbadol
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Summary:Buprenorphine is used for canine postoperative pain management. This study aimed to describe the pharmacokinetics and evaluate the analgesic efficacy of buprenorphine (Simbadol, 1.8 mg/mL) administered by different routes in dogs undergoing ovariohysterectomy. Twenty-four dogs were included in a randomized, prospective, masked, clinical trial. Buprenorphine (0.02 mg/kg) was administered intravenously (IV), intramuscularly (IM) or subcutaneously (SC) (n = 8/group) 0.5 h before general anesthesia with propofol-isoflurane. Carprofen (4.4 mg/kg SC) was administered after anesthetic induction and before ovariohysterectomy. Pain was scored using the short-form Glasgow composite pain scale for dogs (SF-GCPS). Dogs were administered morphine (0.25 mg/kg IV) when SF-GCPS scores were ≥ 5/20. Blood sampling was performed up to 720 min after drug administration. Plasma buprenorphine and norbuprenorphine concentrations were analyzed using liquid chromatography mass spectrometry. Pharmacokinetics of buprenorphine was described using a non-compartmental model (PK Solver 2.0). Statistical analysis was performed using linear mixed models and Fisher's exact test (p 
ISSN:1746-6148
1746-6148
DOI:10.1186/s12917-020-02364-w