Characterization of spatial lipidomic signatures in tick-bitten guinea pig skin as a model for host-vector-pathogen interaction profiling

Here, we demonstrate the adaptability of spatial "omics" methods to identify interphylum processes regulated at the vector-host interface of ticks during a mammalian blood meal. This approach enables a better understanding of complex bipartite or tripartite molecular interactions between h...

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Bibliographic Details
Published in:mSystems 2023-12, Vol.8 (6), p.e0092723-e0092723
Main Authors: Scott, Alison J, Smith, Alexis A, Heeren, Ron M A, Pal, Utpal, Ernst, Robert K
Format: Article
Language:English
Subjects:
Adaptability
Animals
Arthropods
Dermis
Disease transmission
Electrons
Gelatin
guinea pig
Guinea Pigs
Hair
Histology
Host-Pathogen Interactions
host-vector interaction
Ixodes
Lipidomics
Lipids
Mammals
Mass spectroscopy
Mouthparts
Observation
Pathogenesis and Host Response
Pathogens
Sectioning
Skin
spatial lipidomics
Therapeutic targets
Ticks
vector-borne diseases
Vectors
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Description
Summary:Here, we demonstrate the adaptability of spatial "omics" methods to identify interphylum processes regulated at the vector-host interface of ticks during a mammalian blood meal. This approach enables a better understanding of complex bipartite or tripartite molecular interactions between hosts, arthropod vectors and transmitted pathogens, and contributes toward the development of spatially aware therapeutic target discovery and description.
ISSN:2379-5077
2379-5077
DOI:10.1128/msystems.00927-23