Active Compound from An Indonesian Endophytic Fungus Talaromyces veruculosus BioMCC-f.EP.2165 Inhibiting Plasmodium falciparum Dihydroorotate Dehydrogenase as Antimalarial Agent

An Indonesian endophytic fungus Talaromyces veruculosus BioMCC-f.EP.2165, was cultured to find compounds that showing inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase ( Pf DHODH). Preliminary extraction test (PET) was conducted for examination of active compounds proper...

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Bibliographic Details
Published in:BIO web of conferences 2024, Vol.117, p.1049
Main Authors: Nugroho, Nuki Bambang, Pramisandi, Amila, Siska, Eka, Chrisnayanti, Evita, Hidayati, Dyah Noor, Suryani, Suryani, Nurlaila, Nurlaila, Waluyo, Danang, Prabandari, Erwahyuni Endang, Nozaki, Tomoyoshi
Format: Article
Language:English
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Summary:An Indonesian endophytic fungus Talaromyces veruculosus BioMCC-f.EP.2165, was cultured to find compounds that showing inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase ( Pf DHODH). Preliminary extraction test (PET) was conducted for examination of active compounds properties in fungal culture broth. Active compounds were extracted and purified based on a method derived from PET result. We isolated altenusin as an active compound from the fungal culture extract. Although, altenusin has been reported previously as an inhibitor of Pf DHODH and inhibited the proliferation of Plasmodium falciparum 3D7, we isolated this compound from endophytic Talaromyces fungus for the first time.
ISSN:2117-4458
2117-4458
DOI:10.1051/bioconf/202411701049