Active Compound from An Indonesian Endophytic Fungus Talaromyces veruculosus BioMCC-f.EP.2165 Inhibiting Plasmodium falciparum Dihydroorotate Dehydrogenase as Antimalarial Agent

An Indonesian endophytic fungus Talaromyces veruculosus BioMCC-f.EP.2165, was cultured to find compounds that showing inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase ( Pf DHODH). Preliminary extraction test (PET) was conducted for examination of active compounds proper...

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Published in:BIO web of conferences 2024, Vol.117, p.1049
Main Authors: Nugroho, Nuki Bambang, Pramisandi, Amila, Siska, Eka, Chrisnayanti, Evita, Hidayati, Dyah Noor, Suryani, Suryani, Nurlaila, Nurlaila, Waluyo, Danang, Prabandari, Erwahyuni Endang, Nozaki, Tomoyoshi
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container_title BIO web of conferences
container_volume 117
creator Nugroho, Nuki Bambang
Pramisandi, Amila
Siska, Eka
Chrisnayanti, Evita
Hidayati, Dyah Noor
Suryani, Suryani
Nurlaila, Nurlaila
Waluyo, Danang
Prabandari, Erwahyuni Endang
Nozaki, Tomoyoshi
description An Indonesian endophytic fungus Talaromyces veruculosus BioMCC-f.EP.2165, was cultured to find compounds that showing inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase ( Pf DHODH). Preliminary extraction test (PET) was conducted for examination of active compounds properties in fungal culture broth. Active compounds were extracted and purified based on a method derived from PET result. We isolated altenusin as an active compound from the fungal culture extract. Although, altenusin has been reported previously as an inhibitor of Pf DHODH and inhibited the proliferation of Plasmodium falciparum 3D7, we isolated this compound from endophytic Talaromyces fungus for the first time.
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title Active Compound from An Indonesian Endophytic Fungus Talaromyces veruculosus BioMCC-f.EP.2165 Inhibiting Plasmodium falciparum Dihydroorotate Dehydrogenase as Antimalarial Agent
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