Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment

• Published in: BMC cardiovascular disorders 2019-09, Vol.19 (1), p.211-211, Article 211
• Main Authors: Noronha Osório, Daniel, Viana-Soares, Ricardo, Marto, João Pedro, Mendonça, Marcelo D, Silva, Hugo P, Quaresma, Cláudia, Viana-Baptista, Miguel, Gamboa, Hugo, Vieira, Helena L A
• Format: Article
• Language: English
• Subjects: Analysis; Autonomic nervous system; Baroreceptors; Cardiac conditioning; Deflation (Economics); EKG; Electrocardiography; Heart rate; Heart rate variability; Ischemia; Nervous system; Parasympathetic nervous system; Remote ischemic conditioning; Sympathetic nervous system; Vagus nerve
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-019-1181-5

Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart. The underlying mechanisms of RIC are still not fully understood, and it is hypothesized they are mediated either by humoral factors, immune cells and/or the autonomic nervous system. Herein, heart rate variability (HRV) was used to evaluate the electrophysiological processes occurring in the heart during RIC and, in turn to assess the role of autonomic nervous system. Healthy subjects were submitted to RIC protocol and electrocardiography (ECG) was used to evaluate HRV, by assessing the variability of time intervals between two consecutive heart beats. This is a pilot study based on the analysis of 18 ECG from healthy subjects submitted to RIC. HRV was characterized in three domains (time, frequency and non-linear features) that can be correlated with the autonomic nervous system function. RIC procedure increased significantly the non-linear parameter SD2, which is associated with long term HRV. This effect was observed in all subjects and in the senior (> 60 years-old) subset analysis. SD2 increase suggests an activation of both parasympathetic and sympathetic nervous system, namely via fast vagal response (parasympathetic) and the slow sympathetic response to the baroreceptors stimulation. RIC procedure modulates both parasympathetic and sympathetic autonomic nervous system. Furthermore, this modulation is more pronounced in the senior subset of subjects. Therefore, the autonomic nervous system regulation could be one of the mechanisms for RIC therapeutic effectiveness.