Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue

Dengue is the most common vector-borne viral disease worldwide. Most cases are mild, but some evolve into severe dengue (SD), with high lethality. Therefore, it is important to identify biomarkers of severe disease to improve outcomes and judiciously utilize resources. One hundred forty-five confirm...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2023-02, Vol.17 (2), p.e0010750-e0010750
Main Authors: Bernal, Cynthia, Ping, Sara, Rojas, Alejandra, Caballero, Oliver, Stittleburg, Victoria, de Guillén, Yvalena, Langjahr, Patricia, Pinsky, Benjamin A, Von-Horoch, Marta, Luraschi, Patricia, Cabral, Sandra, Sánchez, María Cecilia, Torres, Aurelia, Cardozo, Fátima, Waggoner, Jesse J
Format: Article
Language:English
Subjects:
Adult
Antibodies
Antibodies, Viral
Antigens
Biological markers
Biology and life sciences
Biomarkers
Care and treatment
Chymase
Chymases
Clinical outcomes
Comorbidity
Confidence intervals
Dengue
Dengue fever
Dengue hemorrhagic fever
Development and progression
Enrollments
Enzyme-Linked Immunosorbent Assay
Epidemics
Evaluation
Female
Flavivirus
Gender
Health aspects
Human diseases
Humans
Identification and classification
Illnesses
Immunoglobulin G
Immunoglobulin M
Laboratories
Lethality
Lipopolysaccharides
Lymphocytes
Male
Medicine and Health Sciences
Multiplexing
Prognosis
Regression models
Research and Analysis Methods
Serology
Serum
Severe Dengue - diagnosis
Statistical analysis
Tropical diseases
Vector-borne diseases
Viral diseases
Viroses
Viruses
Zika virus
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Description
Summary:Dengue is the most common vector-borne viral disease worldwide. Most cases are mild, but some evolve into severe dengue (SD), with high lethality. Therefore, it is important to identify biomarkers of severe disease to improve outcomes and judiciously utilize resources. One hundred forty-five confirmed dengue cases (median age, 42; range
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0010750