Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs: newer formulation techniques, current marketed scenario and patents

• Published in: Drug delivery 2020-11, Vol.27 (1), p.1625-1643
• Main Authors: Alshehri, Sultan, Imam, Syed Sarim, Hussain, Afzal, Altamimi, Mohammad A, Alruwaili, Nabil K, Alotaibi, Fahad, Alanazi, Abdullah, Shakeel, Faiyaz
• Format: Article
• Language: English
• Subjects: bioavailability; Biological Availability; Chemistry, Pharmaceutical - methods; dissolution; Drug Carriers - chemistry; marketed formulations; patent status; Pharmaceutical Preparations - chemistry; Pharmaceutical Preparations - metabolism; Polymers - chemistry; solid dispersion; Solubility; Water - chemistry
• ISSN: 1071-7544; 1521-0464
• DOI: 10.1080/10717544.2020.1846638

In the last few decades, solid dispersion (SD) technology had been studied as an approach to produce an amorphous carrier to enhance the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. The use of suitable carrier and methodology in the preparation of SDs play a significant role in the biological behavior of the SDs. SDs have been prepared using a variety of pharmaceutically acceptable polymers utilizing various novel technologies. In the recent years, much attention has been paid toward the use of novel carriers and methodologies in exploring novel types of SDs to enhance therapeutic efficacy and bioavailability. The use of novel carriers and methodologies would be very beneficial for formulation scientists to develop some SDs-based formulations for their commercial use and clinical applications. In the present review, current literature of novel methodologies for SD preparation to enhance the dissolution rate, solubility, therapeutic efficacy, and bioavailability of poorly water-soluble drugs has been summarized and analyzed. Further, the current status of SDs, patent status, and future prospects have also been discussed.