Efficacy of recombinant human granulocyte colony stimulating factor in very-low-birth-weight infants with early neutropenia

Background/Purpose Neutropenia is a risk factor for nosocomial infections (NI) in very-low-birth-weight (VLBW) infants. Although recombinant human granulocyte colony stimulating factor (rhG-CSF) increases the neutrophil counts in neutropenic VLBW infants, its long-term efficacy for early neutropenia...

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Bibliographic Details
Published in:Journal of the Formosan Medical Association 2015-02, Vol.114 (2), p.174-179
Main Authors: Teng, Ru-Jeng, Wu, Tzong-Jin, Sharma, Renu, Garrison, Robert D, Hudak, Mark L
Format: Article
Language:English
Subjects:
Case-Control Studies
Cross Infection - prevention & control
Female
Florida
Gestational Age
Granulocyte Colony-Stimulating Factor - therapeutic use
granulocyte-colony-stimulating-factor
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Intensive Care Units, Neonatal
Internal Medicine
Leukocyte Count
Logistic Models
Male
Multivariate Analysis
neutropenia
Neutropenia - complications
Neutropenia - drug therapy
Neutropenia - mortality
nosocomial infection
Recombinant Proteins - therapeutic use
very-low-birth-weight
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Summary:Background/Purpose Neutropenia is a risk factor for nosocomial infections (NI) in very-low-birth-weight (VLBW) infants. Although recombinant human granulocyte colony stimulating factor (rhG-CSF) increases the neutrophil counts in neutropenic VLBW infants, its long-term efficacy for early neutropenia (EN) remains unknown. Methods In this case-controlled study, charts of VLBW recipients of rhG-CSF for EN (total neutrophil count
ISSN:0929-6646
DOI:10.1016/j.jfma.2012.10.009