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Efficacy of recombinant human granulocyte colony stimulating factor in very-low-birth-weight infants with early neutropenia
Background/Purpose Neutropenia is a risk factor for nosocomial infections (NI) in very-low-birth-weight (VLBW) infants. Although recombinant human granulocyte colony stimulating factor (rhG-CSF) increases the neutrophil counts in neutropenic VLBW infants, its long-term efficacy for early neutropenia...
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| Published in: | Journal of the Formosan Medical Association 2015-02, Vol.114 (2), p.174-179 |
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| container_end_page | 179 |
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| container_title | Journal of the Formosan Medical Association |
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| creator | Teng, Ru-Jeng Wu, Tzong-Jin Sharma, Renu Garrison, Robert D Hudak, Mark L |
| description | Background/Purpose Neutropenia is a risk factor for nosocomial infections (NI) in very-low-birth-weight (VLBW) infants. Although recombinant human granulocyte colony stimulating factor (rhG-CSF) increases the neutrophil counts in neutropenic VLBW infants, its long-term efficacy for early neutropenia (EN) remains unknown. Methods In this case-controlled study, charts of VLBW recipients of rhG-CSF for EN (total neutrophil count |
| doi_str_mv | 10.1016/j.jfma.2012.10.009 |
| format | article |
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Although recombinant human granulocyte colony stimulating factor (rhG-CSF) increases the neutrophil counts in neutropenic VLBW infants, its long-term efficacy for early neutropenia (EN) remains unknown. Methods In this case-controlled study, charts of VLBW recipients of rhG-CSF for EN (total neutrophil count <1.5 × 109 /L during first 7 days) were reviewed and compared to gestational age, total neutrophil count, and birth weight matched infants unexposed to rhG-CSF. Results Twenty-seven infants were identified in each group. Mortality and morbidity did not differ between the two groups. Rate of NI (16/27 vs. 4/27, p = 0.002, odds ratio = 8.36) as well as the total number of episodes of NI (22 vs. 4, p = 0.007) were higher in rhG-CSF (+) group than in the rhG-CSF (–) group. Conclusion Our experience does not show benefit in empirical use of rhG-CSF in preventing NI in VLBW infants with EN.</description><identifier>ISSN: 0929-6646</identifier><identifier>DOI: 10.1016/j.jfma.2012.10.009</identifier><identifier>PMID: 25678180</identifier><language>eng</language><publisher>Singapore: Elsevier B.V</publisher><subject>Case-Control Studies ; Cross Infection - prevention & control ; Female ; Florida ; Gestational Age ; Granulocyte Colony-Stimulating Factor - therapeutic use ; granulocyte-colony-stimulating-factor ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Intensive Care Units, Neonatal ; Internal Medicine ; Leukocyte Count ; Logistic Models ; Male ; Multivariate Analysis ; neutropenia ; Neutropenia - complications ; Neutropenia - drug therapy ; Neutropenia - mortality ; nosocomial infection ; Recombinant Proteins - therapeutic use ; very-low-birth-weight</subject><ispartof>Journal of the Formosan Medical Association, 2015-02, Vol.114 (2), p.174-179</ispartof><rights>2012</rights><rights>Copyright © 2012. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-3bef11da9b30a18b9eba0c5b8ec141a9631d6f2a2261801f8a5c8b394d96a6283</citedby><cites>FETCH-LOGICAL-c547t-3bef11da9b30a18b9eba0c5b8ec141a9631d6f2a2261801f8a5c8b394d96a6283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25678180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teng, Ru-Jeng</creatorcontrib><creatorcontrib>Wu, Tzong-Jin</creatorcontrib><creatorcontrib>Sharma, Renu</creatorcontrib><creatorcontrib>Garrison, Robert D</creatorcontrib><creatorcontrib>Hudak, Mark L</creatorcontrib><title>Efficacy of recombinant human granulocyte colony stimulating factor in very-low-birth-weight infants with early neutropenia</title><title>Journal of the Formosan Medical Association</title><addtitle>J Formos Med Assoc</addtitle><description>Background/Purpose Neutropenia is a risk factor for nosocomial infections (NI) in very-low-birth-weight (VLBW) infants. Although recombinant human granulocyte colony stimulating factor (rhG-CSF) increases the neutrophil counts in neutropenic VLBW infants, its long-term efficacy for early neutropenia (EN) remains unknown. Methods In this case-controlled study, charts of VLBW recipients of rhG-CSF for EN (total neutrophil count <1.5 × 109 /L during first 7 days) were reviewed and compared to gestational age, total neutrophil count, and birth weight matched infants unexposed to rhG-CSF. Results Twenty-seven infants were identified in each group. Mortality and morbidity did not differ between the two groups. Rate of NI (16/27 vs. 4/27, p = 0.002, odds ratio = 8.36) as well as the total number of episodes of NI (22 vs. 4, p = 0.007) were higher in rhG-CSF (+) group than in the rhG-CSF (–) group. Conclusion Our experience does not show benefit in empirical use of rhG-CSF in preventing NI in VLBW infants with EN.</description><subject>Case-Control Studies</subject><subject>Cross Infection - prevention & control</subject><subject>Female</subject><subject>Florida</subject><subject>Gestational Age</subject><subject>Granulocyte Colony-Stimulating Factor - therapeutic use</subject><subject>granulocyte-colony-stimulating-factor</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Very Low Birth Weight</subject><subject>Intensive Care Units, Neonatal</subject><subject>Internal Medicine</subject><subject>Leukocyte Count</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Multivariate Analysis</subject><subject>neutropenia</subject><subject>Neutropenia - complications</subject><subject>Neutropenia - drug therapy</subject><subject>Neutropenia - mortality</subject><subject>nosocomial infection</subject><subject>Recombinant Proteins - therapeutic use</subject><subject>very-low-birth-weight</subject><issn>0929-6646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kkGP1SAUhbvQOOPoH3BhWLrpE2ihJTEmZjLqJJO4UNfklsJ7VApPoPPS-OelvnEWLlyRHM455PLdqnpF8I5gwt9Ou8nMsKOY0CLsMBZPqkssqKg5b_lF9TylCeOWC8GfVReU8a4nPb6sft0YYxWoFQWDolZhHqwHn9FhmcGjfQS_uKDWrJEKLvgVpWznxUG2fo8MqBwish7d67jWLpzqwcZ8qE_a7g-5XJjSldDJ5gPSEN2KvF5yDEftLbyonhpwSb98OK-q7x9vvl1_ru--fLq9_nBXK9Z2uW4GbQgZQQwNBtIPQg-AFRt6rUhLQPCGjNxQoJSXkYjpgal-aEQ7Cg6c9s1VdXvuHQNM8hjtDHGVAaz8I4S4lxCzVU5L6IShTTcKtuUH0gNRLcOD6qEjHWOl68256xjDz0WnLGeblHYOvA5LkoQzxijhjShWeraqGFKK2jw-TbDcoMlJbtDkBm3TCrQSev3QvwyzHh8jf4kVw7uzQZcfu7c6yqSs9kqPtuDLZST7__73_8SVs75sgPuhV52msERfWEgiE5VYft1WaNsgQjFmmNPmN3tgwWM</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Teng, Ru-Jeng</creator><creator>Wu, Tzong-Jin</creator><creator>Sharma, Renu</creator><creator>Garrison, Robert D</creator><creator>Hudak, Mark L</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20150201</creationdate><title>Efficacy of recombinant human granulocyte colony stimulating factor in very-low-birth-weight infants with early neutropenia</title><author>Teng, Ru-Jeng ; Wu, Tzong-Jin ; Sharma, Renu ; Garrison, Robert D ; Hudak, Mark L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-3bef11da9b30a18b9eba0c5b8ec141a9631d6f2a2261801f8a5c8b394d96a6283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Case-Control Studies</topic><topic>Cross Infection - prevention & control</topic><topic>Female</topic><topic>Florida</topic><topic>Gestational Age</topic><topic>Granulocyte Colony-Stimulating Factor - therapeutic use</topic><topic>granulocyte-colony-stimulating-factor</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Very Low Birth Weight</topic><topic>Intensive Care Units, Neonatal</topic><topic>Internal Medicine</topic><topic>Leukocyte Count</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Multivariate Analysis</topic><topic>neutropenia</topic><topic>Neutropenia - complications</topic><topic>Neutropenia - drug therapy</topic><topic>Neutropenia - mortality</topic><topic>nosocomial infection</topic><topic>Recombinant Proteins - therapeutic use</topic><topic>very-low-birth-weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teng, Ru-Jeng</creatorcontrib><creatorcontrib>Wu, Tzong-Jin</creatorcontrib><creatorcontrib>Sharma, Renu</creatorcontrib><creatorcontrib>Garrison, Robert D</creatorcontrib><creatorcontrib>Hudak, Mark L</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of the Formosan Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teng, Ru-Jeng</au><au>Wu, Tzong-Jin</au><au>Sharma, Renu</au><au>Garrison, Robert D</au><au>Hudak, Mark L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of recombinant human granulocyte colony stimulating factor in very-low-birth-weight infants with early neutropenia</atitle><jtitle>Journal of the Formosan Medical Association</jtitle><addtitle>J Formos Med Assoc</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>114</volume><issue>2</issue><spage>174</spage><epage>179</epage><pages>174-179</pages><issn>0929-6646</issn><abstract>Background/Purpose Neutropenia is a risk factor for nosocomial infections (NI) in very-low-birth-weight (VLBW) infants. Although recombinant human granulocyte colony stimulating factor (rhG-CSF) increases the neutrophil counts in neutropenic VLBW infants, its long-term efficacy for early neutropenia (EN) remains unknown. Methods In this case-controlled study, charts of VLBW recipients of rhG-CSF for EN (total neutrophil count <1.5 × 109 /L during first 7 days) were reviewed and compared to gestational age, total neutrophil count, and birth weight matched infants unexposed to rhG-CSF. Results Twenty-seven infants were identified in each group. Mortality and morbidity did not differ between the two groups. Rate of NI (16/27 vs. 4/27, p = 0.002, odds ratio = 8.36) as well as the total number of episodes of NI (22 vs. 4, p = 0.007) were higher in rhG-CSF (+) group than in the rhG-CSF (–) group. Conclusion Our experience does not show benefit in empirical use of rhG-CSF in preventing NI in VLBW infants with EN.</abstract><cop>Singapore</cop><pub>Elsevier B.V</pub><pmid>25678180</pmid><doi>10.1016/j.jfma.2012.10.009</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Case-Control Studies Cross Infection - prevention & control Female Florida Gestational Age Granulocyte Colony-Stimulating Factor - therapeutic use granulocyte-colony-stimulating-factor Humans Infant Infant, Newborn Infant, Premature Infant, Very Low Birth Weight Intensive Care Units, Neonatal Internal Medicine Leukocyte Count Logistic Models Male Multivariate Analysis neutropenia Neutropenia - complications Neutropenia - drug therapy Neutropenia - mortality nosocomial infection Recombinant Proteins - therapeutic use very-low-birth-weight |
| title | Efficacy of recombinant human granulocyte colony stimulating factor in very-low-birth-weight infants with early neutropenia |
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