Chemerin level and the relation to insulin resistance in chronic kidney disease

Chemerin has been associated with different components of the metabolic syndrome, including hypertension, hyperlipidemia, and insulin resistance (IR). The aim of this study was to evaluate serum chemerin level in chronic kidney disease (CKD) patients and its relation to IR. This study was conducted...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2019-11, Vol.30 (6), p.1381-1388
Main Authors: El-Khashab, Sahier, Gamil, Mona, Ali, Ahmed, El-Khashab, Omar, El-Khatib, Mohamed, Mohamed, Kariman, El-Shehaby, Amal, Hamed, Soha
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Blood pressure
Body mass index
Chemokines - blood
Cholesterol
Chronic kidney failure
Fasting
Female
Hemodialysis
Hepatitis
Humans
Hyperlipidemia
Hypertension
Insulin Resistance
Kidney diseases
Laboratories
Male
Metabolism
Middle Aged
Obesity
Patients
Proteins
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - metabolism
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Summary:Chemerin has been associated with different components of the metabolic syndrome, including hypertension, hyperlipidemia, and insulin resistance (IR). The aim of this study was to evaluate serum chemerin level in chronic kidney disease (CKD) patients and its relation to IR. This study was conducted on 80 participants who were classified into three groups: Group I (30 CKD patients with mean age 53 ± 12 years), Group II (30 patients with end-stage renal disease on regular hemodialysis with mean age 48 ± 14.8 years) and Group III having 20 healthy age-and sex-matched controls. Serum chemerin level, fasting blood sugar, fasting insulin, HOMA-IR index calculation, urea, creatinine, estimated glomerular filtration rate, total cholesterol, and triglyceride were measured. Body composition was assessed by dual-energy X-ray absorptiometry. In Groups I and II, we found a significantly higher mean chemerin level compared to healthy controls (P
ISSN:1319-2442
2320-3838
DOI:10.4103/1319-2442.275482