Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from Artemisia annua L

Artemisinin is an anti-malarial sesquiterpene lactone derived from L. (Asteraceae family). One of the most widely used modes of treatment for malaria is an artemisinin-based combination therapy. Artemisinin and its associated compounds have a variety of pharmacological qualities that have helped ach...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-05, Vol.27 (9), p.3040
Main Authors: Al-Khayri, Jameel M, Sudheer, Wudali N, Lakshmaiah, Vasantha V, Mukherjee, Epsita, Nizam, Aatika, Thiruvengadam, Muthu, Nagella, Praveen, Alessa, Fatima M, Al-Mssallem, Muneera Q, Rezk, Adel A, Shehata, Wael F, Attimarad, Mahesh
Format: Article
Language:English
Subjects:
Acids
Agrobacterium rhizogenes
Antimalarials - metabolism
Artemisia annua
Artemisia annua - genetics
Artemisia annua - metabolism
Artemisinin
Artemisinins - metabolism
bioreactor
Bioreactors
Biosynthesis
Biotechnology
Cell culture
cell suspension culture
elicitation
Genes
Genetic engineering
Herbal medicine
Malaria
Metabolic Engineering
Metabolism
Metabolites
Propagation
Review
Seeds
Tissue culture
Trichomes
Trichomes - metabolism
Vector-borne diseases
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Summary:Artemisinin is an anti-malarial sesquiterpene lactone derived from L. (Asteraceae family). One of the most widely used modes of treatment for malaria is an artemisinin-based combination therapy. Artemisinin and its associated compounds have a variety of pharmacological qualities that have helped achieve economic prominence in recent years. So far, research on the biosynthesis of this bioactive metabolite has revealed that it is produced in glandular trichomes and that the genes responsible for its production must be overexpressed in order to meet demand. Using biotechnological applications such as tissue culture, genetic engineering, and bioreactor-based approaches would aid in the upregulation of artemisinin yield, which is needed for the future. The current review focuses on the tissue culture aspects of propagation of and production of artemisinin from L. cell and organ cultures. The review also focuses on elicitation strategies in cell and organ cultures, as well as artemisinin biosynthesis and metabolic engineering of biosynthetic genes in and plant model systems.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27093040