Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes

Adiponectin, an adipose tissue-derived hormone, plays integral roles in lipid and glucose metabolism in peripheral tissues, such as the skeletal muscle, adipose tissue, and liver. Moreover, it has also been shown to have an impact on metabolic processes in the central nervous system. Astrocytes comp...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-02, Vol.22 (4), p.1587
Main Authors: Song, Nuri, Jeong, Da Yeon, Tu, Thai Hien, Park, Byong Seo, Yang, Hye Rim, Kim, Ye Jin, Kim, Jae Kwang, Park, Joon Tae, Yeh, Jung-Yong, Yang, Sunggu, Kim, Jae Geun
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - genetics
Adiponectin - metabolism
Adipose tissue
Animals
astrocyte
Astrocytes
Astrocytes - cytology
Astrocytes - metabolism
Availability
Blood vessels
Central nervous system
Energy
Energy Metabolism
Fatty acids
Female
Glucose
Glucose - metabolism
Glycolysis
Homeostasis
Hypothalamus
Hypothalamus - cytology
Hypothalamus - metabolism
Lipid metabolism
Lipids
Male
metabolic diseases
Metabolism
Metabolites
Mice
Mice, Inbred C57BL
Muscles
Neurons
Nutrient availability
Nutrients - metabolism
Oxidation
Oxidation-Reduction
Phosphorylation
Proteins
Skeletal muscle
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Summary:Adiponectin, an adipose tissue-derived hormone, plays integral roles in lipid and glucose metabolism in peripheral tissues, such as the skeletal muscle, adipose tissue, and liver. Moreover, it has also been shown to have an impact on metabolic processes in the central nervous system. Astrocytes comprise the most abundant cell type in the central nervous system and actively participate in metabolic processes between blood vessels and neurons. However, the ability of adiponectin to control nutrient metabolism in astrocytes has not yet been fully elucidated. In this study, we investigated the effects of adiponectin on multiple metabolic processes in hypothalamic astrocytes. Adiponectin enhanced glucose uptake, glycolytic processes and fatty acid oxidation in cultured primary hypothalamic astrocytes. In line with these findings, we also found that adiponectin treatment effectively enhanced synthesis and release of monocarboxylates. Overall, these data suggested that adiponectin triggers catabolic processes in astrocytes, thereby enhancing nutrient availability in the hypothalamus.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22041587