Is Myasthenia Gravis a Real Complication of the COVID-19 Vaccine? A Case Report-Based Systematic Review

Background. Myasthenia gravis (MG) is a neuromuscular, autoimmune disease that causes weakness by impairing neuromuscular transmission. According to reports, vaccines can lead to autoimmunity in different ways, and COVID-19 vaccines are suggested to trigger MG. We conducted this systematic review to...

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Bibliographic Details
Published in:The Canadian journal of infectious diseases & medical microbiology 2022-09, Vol.2022, p.1-7
Main Authors: Mirmosayyeb, Omid, Moases Ghaffary, Elham, Mazdak, Mahsa, Bagheri, Zahra, Bagherieh, Sara, Shaygannejad, Vahid
Format: Article
Language:English
Subjects:
Antibodies
Autoimmune diseases
Autoimmunity
BCG
BCG vaccines
Case reports
Case studies
Coronaviruses
COVID-19
COVID-19 vaccines
Demographics
Diplopia
Disease transmission
Dysarthria
Dysphagia
Electromyography
Fever
Guillain-Barre syndrome
Infections
Infectious diseases
Laboratories
Medical research
Medicine, Experimental
Muscles
Myasthenia gravis
Nervous system
Neurologic manifestations of general diseases
Neuromuscular junctions
Neuromuscular transmission
Pandemics
Pathogens
Patients
Respiratory diseases
Review
Risk factors
Severe acute respiratory syndrome coronavirus 2
Signs and symptoms
Steroids
Systematic review
Thymus gland
Vaccination
Vaccines
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Summary:Background. Myasthenia gravis (MG) is a neuromuscular, autoimmune disease that causes weakness by impairing neuromuscular transmission. According to reports, vaccines can lead to autoimmunity in different ways, and COVID-19 vaccines are suggested to trigger MG. We conducted this systematic review to assess MG patients after the COVID-19 vaccination. Methods. We collected 231 studies from four databases from inception to 26 March 2022. Results. 4 case studies were selected from 231 research studies, and data were extracted based on inclusion criteria. In all cases, MG was reported following COVID-19 vaccination. Symptoms such as muscle weakness, numbness, and ptosis were common. The MG was confirmed through RNST, MRC, NCS, and AchR-binding antibody titer tests. Conclusion. Although all cases of MG were diagnosed following appropriate tests, the sample size was small; therefore, further investigation is required to demonstrate the possible association between MG and COVID-19 vaccination.
ISSN:1712-9532
1918-1493
DOI:10.1155/2022/5009450