Serum Cystatin C is Associated with Depression After Intracerebral Hemorrhage

Cystatins are associated with neuronal degeneration and nervous system healing. Cystatin C (Cys C) has recently been linked to brain injury and immunological inflammation. This study aimed to determine the relationship between serum Cys C levels and depression following intracranial hemorrhage (ICH)...

Full description

Saved in:
Bibliographic Details
Published in:Neuropsychiatric disease and treatment 2023-01, Vol.19, p.1117-1126
Main Authors: Zhu, Lei, Yu, Chuanqing, Chang, Yueyue, Sun, Shiyu, Sun, Zhongwu
Format: Article
Language:English
Subjects:
Complications and side effects
cystatin c
depression
Depression, Mental
Intracerebral hemorrhage
Original Research
post-stroke depression
Risk factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cystatins are associated with neuronal degeneration and nervous system healing. Cystatin C (Cys C) has recently been linked to brain injury and immunological inflammation. This study aimed to determine the relationship between serum Cys C levels and depression following intracranial hemorrhage (ICH). Between September 2020 and December 2022, 337 patients with ICH were sequentially recruited and followed up for three months. The post-stroke depression (PSD) and non-PSD groups were separated based on the 17-item Hamilton Depression Rating Scale (HAMD). The PSD diagnosis was established based on the DSM-IV criteria. Cys-C levels were documented within twenty-four hours of admission. Three months after ICH, 93 (27.6%) of 337 enrolled patients were diagnosed with depression. The Cys C levels were significantly higher in depressed patients than in nondepressed patients after ICH (1.32 vs 1.01; p
ISSN:1176-6328
1178-2021
1178-2021
DOI:10.2147/NDT.S409421