The effect of coarctation degrees on wall shear stress indices

Coarctation of the aorta (CoA) is a congenital tightening of the proximal descending aorta. Flow quantification can be immensely valuable for an early and accurate diagnosis. However, there is a lack of appropriate diagnostic approaches for a variety of cardiovascular diseases, such as CoA. An accur...

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Bibliographic Details
Published in:Scientific reports 2021-06, Vol.11 (1), p.12757-13, Article 12757
Main Authors: Rafiei, Deniz, Abazari, Mohammad Amin, Soltani, M., Alimohammadi, Mona
Format: Article
Language:English
Subjects:
639/166/985
639/166/988
692/4019/592/75/593/1301
Aorta
Aorta - physiopathology
Aortic Coarctation - physiopathology
Blood flow
Blood Flow Velocity
Cardiovascular diseases
Computer applications
Computer Simulation
Coronary vessels
Hemodynamics
Humanities and Social Sciences
Humans
multidisciplinary
Patients
Science
Science (multidisciplinary)
Shear stress
Stress, Mechanical
Tunica Intima - physiopathology
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Summary:Coarctation of the aorta (CoA) is a congenital tightening of the proximal descending aorta. Flow quantification can be immensely valuable for an early and accurate diagnosis. However, there is a lack of appropriate diagnostic approaches for a variety of cardiovascular diseases, such as CoA. An accurate understanding of the disease depends on measurements of the global haemodynamics (criteria for heart function) and also the local haemodynamics (detailed data on the dynamics of blood flow). Playing a significant role in clinical processes, wall shear stress (WSS) cannot be measured clinically; thus, computation tools are needed to give an insight into this crucial haemodynamic parameter. In the present study, in order to enable the progress of non-invasive approaches that quantify global and local haemodynamics for different CoA severities, innovative computational blueprint simulations that include fluid–solid interaction models are developed. Since there is no clear approach for managing the CoA regarding its severity, this study proposes the use of WSS indices and pressure gradient to better establish a framework for treatment procedures in CoA patients with different severities. This provides a platform for improving CoA therapy on a patient-specific level, in which physicians can perform treatment methods based on WSS indices on top of using a mere experience. Results show how severe CoA affects the aorta in comparison to the milder cases, which can give the medical community valuable information before and after any intervention.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-92104-3