The Role of Dendritic Cells in the Differentiation of T Follicular Helper Cells

T follicular helper cells (TFH) are a subset of recently discovered CD4+ T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions o...

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Bibliographic Details
Published in:Journal of immunology research 2018-01, Vol.2018 (2018), p.1-7
Main Authors: Chang, Lu, Huo, Feifei, Sun, Guangyu, Zou, Xueyang, Yang, Wei
Format: Article
Language:English
Subjects:
Antigen presentation
CD4 antigen
Cell proliferation
Cytokines
Dendritic cells
Germinal centers
Helper cells
Immunology
Ligands
Lymphocytes
Lymphocytes B
Lymphocytes T
Peptides
Review
T cell receptors
Transcription factors
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Summary:T follicular helper cells (TFH) are a subset of recently discovered CD4+ T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions of TFH cells are clear. However, the early differentiation of these cells is not clear. Dendritic cells (DCs) participate in the differentiation of TFH cells. Therefore, this article reviewed the research progress regarding the influence of DCs on the differentiation of TFH cells and their major underlying mechanisms.
ISSN:2314-8861
2314-7156
DOI:10.1155/2018/7281453