Monkeypox Virus Evolution before 2022 Outbreak

Phylogenetic analysis of monkeypox virus genomes showed statistically significant divergence and nascent subclades during the 2022 mpox outbreak. Frequency of G>A/C>T transitions has increased in recent years, probably resulting from apolipoprotein B mRNA editing enzyme catalytic polypeptide 3...

Full description

Saved in:
Bibliographic Details
Published in:Emerging infectious diseases 2023-02, Vol.29 (2), p.451-453
Main Authors: Dumonteil, Eric, Herrera, Claudia, Sabino-Santos, Gilberto
Format: Article
Language:English
Subjects:
Adaptation
Bias
Causes of
Disease Outbreaks
Distribution
DNA viruses
Editing
Enzymes
Epidemics
Epidemiology
evolution
Genetic aspects
Genomes
Human monkeypox
Humans
Identification and classification
Monkeypox virus
Monkeypox virus - genetics
Monkeypox Virus Evolution before 2022 Outbreak
Mpox
Mpox (monkeypox) - epidemiology
MPXV
Outbreaks
Phylogenetics
Phylogeny
Public health
Research Letter
transmission
United States
Virus research
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Phylogenetic analysis of monkeypox virus genomes showed statistically significant divergence and nascent subclades during the 2022 mpox outbreak. Frequency of G>A/C>T transitions has increased in recent years, probably resulting from apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G (APOBEC3) deaminase editing. This microevolutionary pattern most likely reflects community spread of the virus and adaptation to humans.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2902.220962