Caveolin 1 Modulates Aldosterone‐Mediated Pathways of Glucose and Lipid Homeostasis

Background Overactivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav‐1) is involved in glucose/lipid homeostasis and may modulate MR signaling. We investigated the interplay between cav‐1 and aldosterone signaling...

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Bibliographic Details
Published in:Journal of the American Heart Association 2016-10, Vol.5 (10), p.n/a
Main Authors: Baudrand, Rene, Gupta, Nidhi, Garza, Amanda E., Vaidya, Anand, Leopold, Jane A., Hopkins, Paul N., Jeunemaitre, Xavier, Ferri, Claudio, Romero, Jose R., Williams, Jonathan, Loscalzo, Joseph, Adler, Gail K., Williams, Gordon H., Pojoga, Luminita H.
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Adolescent
Adult
Aged
Aldehyde Reductase - genetics
Aldehyde Reductase - metabolism
aldosterone
Aldosterone - metabolism
Animals
Blood Glucose - drug effects
caveolin 1
Caveolin 1 - genetics
Cholesterol - metabolism
dyslipidemia
Dyslipidemias - genetics
Dyslipidemias - metabolism
Eplerenone
Female
Gene Frequency
Glucose - metabolism
Homeostasis
Humans
Hypertriglyceridemia - genetics
Hypertriglyceridemia - metabolism
Insulin - metabolism
insulin resistance
Insulin Resistance - genetics
Lipid Metabolism - genetics
Lipoproteins, HDL - metabolism
Liver - metabolism
Male
Mice
Mice, Knockout
Middle Aged
mineralocorticoid receptor
Mineralocorticoid Receptor Antagonists - pharmacology
NADPH Oxidase 4 - genetics
NADPH Oxidase 4 - metabolism
Original Research
Polymorphism, Single Nucleotide
Receptors, Mineralocorticoid - metabolism
Resistin - genetics
Resistin - metabolism
Retinol-Binding Proteins, Plasma - genetics
Retinol-Binding Proteins, Plasma - metabolism
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - metabolism
Signal Transduction
Spironolactone - analogs & derivatives
Spironolactone - pharmacology
Triglycerides - metabolism
Young Adult
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Summary:Background Overactivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav‐1) is involved in glucose/lipid homeostasis and may modulate MR signaling. We investigated the interplay between cav‐1 and aldosterone signaling in modulating insulin resistance and dyslipidemia in cav‐1–null mice and humans with a prevalent variant in the CAV1 gene. Methods and Results In mouse studies, cav‐1 knockout mice exhibited higher levels of homeostatic model assessment of insulin resistance, cholesterol, and resistin and lower ratios of high‐ to low‐density lipoprotein (all P
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.116.003845