Hepatoprotective effect of biherbal ethanolic extract against paracetamol-induced hepatic damage in albino rats

The combined hepatoprotective effect of Bi-herbal ethanolic extract (BHEE) was evaluated against paracetamol induced hepatic damage in albino rats. Liver function tests and biochemical parameters were estimated using standard kits. Livers were quickly removed and fixed in 10% formalin and subjected...

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Bibliographic Details
Published in:Journal of ayurveda and integrative medicine 2012-10, Vol.3 (4), p.198-203
Main Authors: Anantha, Krishna Chaitanya D, Siva, Reddy Challa, Manohar, Reddy A
Format: Article
Language:English
Subjects:
Acetaminophen
Amaranthaceae
Animals
Biherbal ethanolic extract
Body weight
Care and treatment
Comparative analysis
Dosage and administration
Drug dosages
heptoprotective
Liver diseases
Materia medica, Vegetable
Medical research
Metabolites
Original
paracetamol
Physiological aspects
Plant extracts
Rodents
serum glutamate oxaloacetate transaminase
Toxicity
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Summary:The combined hepatoprotective effect of Bi-herbal ethanolic extract (BHEE) was evaluated against paracetamol induced hepatic damage in albino rats. Liver function tests and biochemical parameters were estimated using standard kits. Livers were quickly removed and fixed in 10% formalin and subjected to histopathological studies. Ethanolic extract from the leaves of Aerva lanata and leaves of Achyranthes aspera at a dose level of 200 mg/kg, 400mg/kg body weight was administered orally once for 3 days. Substantially elevated serum marker enzymes such as SGOT, SGPT, ALP, due to paracetamol treatment were restored towards normal. Biochemical parameters like total protein, total bilirubin, total cholesterol, triglycerides, and urea were also restored towards normal levels. In addition, BHEE significantly decreased the liver weight of paracetamol intoxicated rats. Silymarin at a dose level of 25 mg/kg used as a standard reference also exhibited significant hepatoprotective activity against paracetamol induced hepatotoxicity. The results of this study strongly indicate that BHEE has got a potent hepatoprotective action against paracetamol induced hepatic damage in rats.
ISSN:0975-9476
0976-2809
DOI:10.4103/0975-9476.104436