The usefulness of presepsin in the diagnosis of postoperative infectious complications after gastrectomy for gastric cancer: a prospective cohort study

This prospective study aimed to evaluate presepsin use as a biomarker of on postoperative infectious complications after gastrectomy, compared to C-reactive protein (CRP), white blood cells (WBCs), and neutrophils (Neuts). Overall, 108 patients were enrolled between October 2019 and December 2020. P...

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Bibliographic Details
Published in:Scientific reports 2022-12, Vol.12 (1), p.21289-8, Article 21289
Main Authors: Imai, Yoshiro, Tanaka, Ryo, Honda, Kotaro, Matsuo, Kentaro, Taniguchi, Kohei, Asakuma, Mitsuhiro, Lee, Sang-Woong
Format: Article
Language:English
Subjects:
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692/53
Biomarkers
C-reactive protein
C-Reactive Protein - metabolism
Cohort analysis
Communicable Diseases
Gastrectomy
Gastrectomy - adverse effects
Gastric cancer
Gastrointestinal surgery
Humanities and Social Sciences
Humans
Leukocytes (neutrophilic)
Lipopolysaccharide Receptors
Morbidity
multidisciplinary
Peptide Fragments
Postoperative Complications - diagnosis
Postoperative Complications - etiology
Prospective Studies
Science
Science (multidisciplinary)
Stomach Neoplasms - surgery
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Summary:This prospective study aimed to evaluate presepsin use as a biomarker of on postoperative infectious complications after gastrectomy, compared to C-reactive protein (CRP), white blood cells (WBCs), and neutrophils (Neuts). Overall, 108 patients were enrolled between October 2019 and December 2020. Presepsin, CRP, WBC, and Neut levels were measured preoperatively and on postoperative days (PODs) 1, 3, 5, and 7, using a postoperative morbidity survey. Grade II or higher infectious complications occurred in 18 patients (16.6%). Presepsin levels on all evaluated PODs were significantly higher in the infectious complication group than in the non-complication group ( p  = 0.002, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-24780-8