OPN promotes pro-inflammatory cytokine expression via ERK/JNK pathway and M1 macrophage polarization in Rosacea

Rosacea is a chronic inflammatory dermatosis that involves dysregulation of innate and adaptive immune systems. Osteopontin (OPN) is a phosphorylated glycoprotein produced by a broad range of immune cells such as macrophages, keratinocytes, and T cells. However, the role of OPN in rosacea remains to...

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Bibliographic Details
Published in:Frontiers in immunology 2023, Vol.14, p.1285951-1285951
Main Authors: Tang, Siyi, Hu, Hao, Li, Manhui, Zhang, Kaoyuan, Wu, Qi, Liu, Xiaojuan, Wu, Lin, Yu, Bo, Chen, Xiaofan
Format: Article
Language:English
Subjects:
Cytokines
Dermatitis
Humans
Inflammation
keratinocyte
macrophage
Macrophages
MAP Kinase Signaling System
OPN
Osteopontin
Rosacea
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Summary:Rosacea is a chronic inflammatory dermatosis that involves dysregulation of innate and adaptive immune systems. Osteopontin (OPN) is a phosphorylated glycoprotein produced by a broad range of immune cells such as macrophages, keratinocytes, and T cells. However, the role of OPN in rosacea remains to be elucidated. In this study, it was found that OPN expression was significantly upregulated in rosacea patients and LL37-induced rosacea-like skin inflammation. Transcriptome sequencing results indicated that OPN regulated pro-inflammatory cytokines and promoted macrophage polarization towards M1 phenotype in rosacea-like skin inflammation. , it was demonstrated that intracellular OPN (iOPN) promoted LL37-induced IL1B production through ERK1/2 and JNK pathways in keratinocytes. Moreover, secreted OPN (sOPN) played an important role in keratinocyte-macrophage crosstalk. In conclusion, sOPN and iOPN were identified as key regulators of the innate immune system and played different roles in the pathogenesis of rosacea.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1285951