Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors: Harms or Unexpected Benefits?

There is a need for innovative pharmaceutical intervention in light of the increasing prevalence of metabolic disease and cardiovascular disease. The kidneys' sodium-glucose cotransporter 2 inhibitors (SGLT2) receptors are targeted to reduce glucose reabsorption by SGLT2. Patients with type 2 d...

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Bibliographic Details
Published in:Medicina (Kaunas, Lithuania) Lithuania), 2023-04, Vol.59 (4), p.742
Main Authors: Andreea, Munteanu Madalina, Surabhi, Swarnkar, Razvan-Ionut, Popescu, Lucia, Ciobotaru, Camelia, Nicolae, Emil, Tufanoiu, Tiberiu, Nanea Ioan
Format: Article
Language:English
Subjects:
Body mass index
cardiovascular effects
Carrier proteins
Complications and side effects
Diabetes
Diabetes Mellitus, Type 2
Drugs
Glucagon
Glucose
Glucose metabolism
Health aspects
Heart failure
Humans
Hyperglycemia
Hypoglycemic agents
Hypoglycemic Agents - adverse effects
Insulin resistance
Kidney diseases
Liver cirrhosis
Liver diseases
Metabolism
Physiological aspects
Review
SGLT2 inhibitors
Sodium
Sodium-Glucose Transporter 2 - metabolism
Sodium-Glucose Transporter 2 - therapeutic use
Sodium-Glucose Transporter 2 Inhibitors - adverse effects
Transplants & implants
type 2 diabetes
Urine
White people
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Summary:There is a need for innovative pharmaceutical intervention in light of the increasing prevalence of metabolic disease and cardiovascular disease. The kidneys' sodium-glucose cotransporter 2 inhibitors (SGLT2) receptors are targeted to reduce glucose reabsorption by SGLT2. Patients with type 2 diabetes mellitus (T2DM) benefit the most from reduced blood glucose levels, although this is just one of the numerous physiological consequences. To establish existing understanding and possible advantages and risks for SGLT2 inhibitors in clinical practice, this article will explore the influence of SGLT2 inhibitors on six major organ systems. In addition, this literature review will discuss the benefits and potential drawbacks of SGLT2 inhibitors on various organ systems and their potential application in therapeutic settings.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina59040742