Platelet count as a biomarker for monitoring treatment response and disease recurrence in recurrent epithelial ovarian cancer

We sought to determine the impact of pretreatment plasma platelet levels, dimerized plasmin fragment (D-dimer) and fibrinogen in recurrent epithelial ovarian cancer (EOC) and the impact of platelet levels on SKOV3 cell lines growth and responsiveness to chemotherapy. Under approval of ethical commit...

Full description

Saved in:
Bibliographic Details
Published in:Journal of ovarian research 2020-07, Vol.13 (1), p.78-11, Article 78
Main Authors: Hu, Qinghong, Hada, Abha, Han, Liping
Format: Article
Language:English
Subjects:
Analysis
Apoptosis
Biomarkers
Biomarkers, Tumor - metabolism
Blood platelets
Blood Platelets - pathology
Cancer therapies
Carcinoma, Ovarian Epithelial - pathology
Cell culture
Cell Line, Tumor
Chemotherapy
D-dimer
Disease
Experiments
Female
Fibrin
Fibrinogen
Flow cytometry
Hospitals
Humans
Medical prognosis
Medical research
Multivariate analysis
Neoplasm Recurrence, Local - pathology
Ovarian cancer
Ovarian Neoplasms - pathology
Ovary - pathology
Patients
Plasma
Plasmin
Platelet count
Platelet Count - methods
Platelets
Prognosis
Progression-Free Survival
Recurrence (Disease)
Recurrent EOC
Retrospective Studies
Survival analysis
Thrombocytosis
Tumor cell lines
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We sought to determine the impact of pretreatment plasma platelet levels, dimerized plasmin fragment (D-dimer) and fibrinogen in recurrent epithelial ovarian cancer (EOC) and the impact of platelet levels on SKOV3 cell lines growth and responsiveness to chemotherapy. Under approval of ethical committee, we identified 104 women with recurrent EOC who underwent treatment between January 2010 and February 2015. Reviewing clinical, laboratory, and pathologic records from this retrospective cohort, we analyzed the correlation between pretreatment plasma D-dimer, fibrinogen, platelet levels and clinicopathological parameters, progression free survival (PFS) and overall survival (OS). Inco-culture experiments human ovarian cancer SKOV3 cell lines were used to test the effect of platelet levels on tumor growth and responsiveness to docetaxel. Of the 104 recurrent EOC, thrombocytosis at diagnosis and the decrease of platelet count by less than 25% after primary therapy were associated with worse median progression free survival (P = 0.003;P = 0.021) and median overall survival (P = 0.009;P = 0.009). Mean platelet levels declined at the end of primary therapy(P 
ISSN:1757-2215
1757-2215
DOI:10.1186/s13048-020-00682-z