Supplementing a specific synbiotic suppressed the incidence of AOM/DSS-induced colorectal cancer in mice

• Published in: iScience 2023-06, Vol.26 (6), p.106979-106979, Article 106979
• Main Authors: Wu, Huixia, Wu, Zhengchun, Qiu, Yilan, Zhao, Fangjian, Liao, Minjing, Zhong, Zhihong, Chen, Jian, Zeng, Yiliang, Liu, Rushi
• Format: Article
• Language: English
• Subjects: Cancer; Cancer systems biology; Molecular biology; Molecular medicine
• ISSN: 2589-0042; 2589-0042
• DOI: 10.1016/j.isci.2023.106979

In this study, we evaluated the effect of a specific synbiotic on CAC (AOM/DSS-induced colitis-associated cancer). We confirmed that the synbiotic intervention was able to protect the intestinal barrier and inhibit CAC occurrence via upregulating tight junction proteins and anti-inflammatory cytokines, and downregulating pro-inflammatory cytokines. Moreover, the synbiotic significantly improved the disorder of the colonic microbiota of CAC mice, promoted the formation of SCFAs and the production of secondary bile acids, and alleviated the accumulation of primary bile acids in the CAC mice. Meanwhile, the synbiotic could significantly inhibit the abnormal activation of the intestinal Wnt/β-catenin signaling pathway significantly related to IL-23. In a word, the synbiotic can inhibit the occurrence and development of colorectal tumors and it may be a functional food to prevent inflammation-related colon tumors, and the research also provided a theoretical basis for improving the intestinal microecological environment through diet therapy. [Display omitted] •The synbiotic can alleviate colon inflammation and intestinal mucosal barrier damage•The synbiotic can change the microbiota and the metabolome in CAC mice gut•The synbiotic can inhibit the activation of the Wnt/β-catenin signaling pathway Cancer; Cancer systems biology; Molecular biology; Molecular medicine