Gut metagenomic features of frailty

This study investigates the relationship between frailty severity and gut microbiome characteristics in adults in Kazakhstan. We analyzed 158 participants across four frailty severity (mild to very severe) using metagenomic sequencing of stool samples. Frailty was significantly correlated with age,...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2024-11, Vol.14, p.1486579
Main Authors: Jarmukhanov, Zharkyn, Mukhanbetzhanov, Nurislam, Vinogradova, Elizaveta, Kozhakhmetov, Samat, Kushugulova, Almagul
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bacteria - classification
Bacteria - genetics
Bacteria - isolation & purification
Bacteria - metabolism
Cellular and Infection Microbiology
Feces - microbiology
Female
frailty
Frailty - metabolism
Frailty - microbiology
Gastrointestinal Microbiome - genetics
gut microbiome
Humans
Kazakhstan
Male
Metabolic Networks and Pathways - genetics
metabolic pathways
Metagenome
metagenomics
Metagenomics - methods
microbial diversity
Middle Aged
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Summary:This study investigates the relationship between frailty severity and gut microbiome characteristics in adults in Kazakhstan. We analyzed 158 participants across four frailty severity (mild to very severe) using metagenomic sequencing of stool samples. Frailty was significantly correlated with age, weight, and functional measures like walking speed and grip strength. Microbial diversity decreased significantly with increasing frailty. Beta diversity analysis revealed distinct clustering patterns based at phylum level. Taxonomically, we observed a significant inverse correlation between Firmicutes abundance and frailty. Classes like Clostridia and Erysipelotrichia decreased with frailty, while Bacteroidia and Actinobacteria increased. At the family level, Oscillospiraceae showed a positive correlation with frailty. Functionally, we identified significant correlations between frailty measures and specific metabolic pathways. The frailty index negatively correlated with pathways involved in cobalamin, arginine and molybdenum cofactor biosynthesis and positively correlated with folate biosynthesis. Physical performance measures strongly correlated with pathways related to nucleotide biosynthesis, and one-carbon metabolism. We propose these identified features may constitute a "frailty-associated metabolic signature" in the gut microbiome. This signature suggests multiple interconnected mechanisms through which the microbiome may influence frailty development, including modulation of inflammation, alterations in energy metabolism, and potential impacts on muscle function through microbial metabolites.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2024.1486579